Organ replacement, support and regeneration












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            * Organ replacement, support and regeneration
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            Research activities are focused on several areas: replacement and support of the function 

            in critical conditions, kidney transplantation, uremic toxicity and biocompatibility of di
            Kidney transplantation replaces all renal functions and is currently the best method of tr
            chronic renal failure. The main problem of transplantation is the development of chronic g

            and subsequent graft failure and therefore we focus, in randomised clinical and molecular 
            on the influence of viral infection on graft function in particular and we propose new pre
            pre?emptive procedures based on our results. The dominant topic of research in the area of

            for organ function is the biocompatibility of extracorporeal circulation and uremic toxici
            term goal is to understand the molecular mechanisms responsible for bio?incompatibility of

            methods and to identify new toxic substances of peptide and protein nature in acute and ch
            failure using advanced proteomic methods. Unexplained pathophysiology of sepsis and the la
            treatment of sepsis are the starting point of systematic translation (which uses clinicall

            mammalian biomodels) and clinical research focusing on organ, cellular and molecular mecha
            including the development and evaluation of new therapeutic strategies.






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            * Selected outputs
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            • Reischig T, Kacer M, Jindra P, Hes O, Lysak D, Bouda M. Randomized trial of valganciclov
              valacyclovir prophylaxis for prevention of cytomegalovirus in renal transplantation. Cli
              Nephrol. 2015 Feb 6;10(2):294-304.

            • Karvunidis T, Chvojka J, Lysak D, Sykora R, Krouzecky A, Radej J, Novak I, Matejovic M. 
              chemotherapy-induced cytopenia: effects on microcirculation. Intensive Care Med. 2012 Au
            • Benes J, Chvojka J, Sykora R, Radej J, Krouzecky A, Novak I, Matejovic M. Searching for 

              matter in early septic acute kidney injury: an experimental study. Crit Care. 2011;15(5)
              10.1186/cc10517.
            • Reischig T, Hribova P, Jindra P, Hes O, Bouda M, Treska V, Viklicky O. Long-term outcome

              emptive valganciclovir compared with valacyclovir prophylaxis for prevention of cytomega
              transplantation. J Am Soc Nephrol. 2012 Sep;23(9):1588-97.
            • Swol J, Belohlávek J, Haft JW, Ichiba S, Lorusso R, Peek GJ. Conditions and procedures f

              extracorporeal life support (ECLS) in cardiopulmonary resuscitation (CPR) of adult patie
              2015 Jun 16. pii: 0267659115591622.
            • Belohlavek J, Skalicka H, Boucek T, Kovarnik T, Fichtl J, Smid O, Huptych M, Linhart A. 

              cerebral blood flow and oxygenation monitoring by continuous transcranial Doppler combin
              oximetry in a patient with refractory cardiac arrest treated by extracorporeal life supp
              2014 Nov;29(6):534-8. doi: 10.1177/0267659114529322

            • Havranek S, Belohlavek J, Mlcek M, Huptych M, Boucek T, Svoboda T, Fichtl J, Hrachovina 
              A, Kittnar O. Median frequencies of prolonged ventricular fibrillation treated by V-A EC
              to a return of spontaneous circulation rate. Int J Artif Organs. 2014 Jan;37(1):48-57. d

              ijao.5000291.
            • Belohlavek J, Springer D, Mlcek M, Huptych M, Boucek T, Hodkova G, Fichtl J, Mrazek V, Z
              A, Kittnar O. Early vancomycin, amikacin and gentamicin concentrations in pulmonary arte

              tissue are not affected by VA ECMO (venoarterial extracorporeal membrane oxygenation) in
              prolonged cardiac arrest. Pulm Pharmacol Ther. 2013 Dec;26(6):655-60.
            • Belohlavek J, Mlcek M, Huptych M, Svoboda T, Havranek S, Ostadal P, Boucek T, Kovarnik T

              F, Mrazek V, Belohlavek M, Aschermann M, Linhart A, Kittnar O. Coronary versus carotid b
              coronary perfusion pressure in a pig model of prolonged cardiac arrest treated by differ
              venoarterial ECMO and intraaortic balloon counterpulsation. Crit Care. 2012 Dec 12;16(2)

              10.1186/cc11254.
            • Matejovic M, Ince C, Chawla LS, Blantz R, Molitoris BA, Rosner MH, Okusa MD, Kellum JA, 
              XIII Work Group. Renal Hemodynamics in AKI: In Search of New Treatment Targets. J Am Soc

              Oct 28. pii: ASN.2015030234