Advancing Human Placental Models to Study Endocrine Disrupting Chemicals in Pregn












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            <table style="width:100%; border-collapse:collapse; font-family:Arial, sans-serif; font-si

            <tr> <th style="background:#f4dede; color:#7a0000; text-align:left; padding:16px; width:28
            bottom:3px solid #b40000;"> Leading university: </th> <td style="padding:16px; border-bott
            #b40000;"> Charles University, Faculty of Pharmacy in Hradec Kralove, Department of Pharma

            Toxicology </td> </tr> <tr> <th style="background:#f4dede; color:#7a0000; text-align:left;
            width:28%; border-bottom:3px solid #b40000;"> Project leader: </th> <td style="padding:16p
            bottom:3px solid #b40000;"> Fiona Kumnová </td> </tr> <tr> <th style="background:#f4dede; 

            text-align:left; padding:16px; width:28%;"> Participating<br>universities: </th> <td style
            Charles University, University of Copenhagen, University of Geneva </td> </tr> </table>


            The project investigates endocrine-disrupting chemicals (EDCs), a broad group of environme
            found in plastics, pesticides, cosmetics and pharmaceuticals that interfere with hormonal 

            may contribute to adverse pregnancy outcomes. Because EDCs can cross the placenta, the ini
            together placental research teams from Charles University, the University of Copenhagen an
            of Geneva, each contributing expertise in models such as placental explants, primary troph

            and placental perfusion.

            The aim is to develop human placental models for assessing the effects of EDCs while provi

            term training at partner institutions to gain hands-on experience. This collaboration stre
            interdisciplinary research, expands professional networks and advances knowledge in placen


            Planned activities include laboratory training in Copenhagen on placental perfusion, follo
            in Geneva on trophoblast isolation. A workshop at Charles University will bring master’s a
            together to discuss placental toxicology, experimental models and research methods.


            The project is expected to enhance the participating PhD student’s methodological expertis
            scientific understanding and support comprehensive research on placental responses to EDCs

            cooperation among the three institutions will continue beyond the project, and findings wi
            through conference presentations, publications and outreach materials.