Sepsis ****************************************************************************************** * Sepsis ****************************************************************************************** Sepsis and septic shock are major medical challenges of the 21st century, especially with aging population and the spread of antibiotic resistance. Sepsis continues to show a stead incidence and is a leading cause of in-hospital mortality in developed countries. It is es sepsis affects more than 30 million people worldwide every year, potentially leading to 6 Sepsis is responsible for 30-50% of all deaths in hospitals. Financial costs associated wi enormous; they mount to 20 billion USD/year in USA and 8 billion Euros/year in Europe, thu 5% of total health care costs in developed world. In 2017, sepsis has been recognized as a priority by World Health Organization. Despite huge clinical impact, pathophysiological me sepsis remain only poorly understood. There is a critical need to improve our understandin processes and to develop innovative and efficacious therapies for the treatment of this de Within this research topic, pathophysiology of sepsis is addressed in large animal models of biological complexity, from entire organism responses to cellular, subcellular and mole Based on better understanding of pathophysiology of sepsis, novel therapeutic and diagnost developed and tested. The global spread of antibiotic resistance contributes to the severi and limits therapeutic options. Therefore, molecular epidemiology of antibiotic resistance of antibiotic susceptibility and novel methods for overcoming the antibiotic resistance re major line of research. ****************************************************************************************** * Selected outputs ****************************************************************************************** • Kohoutova M, Horak J, Jarkovska D, Martinkova V, Tegl V, Nalos L, Vistejnova L, Benes J, J, Kuncova J, Matejovic M, Stengl M. Vagus Nerve Stimulation Attenuates Multiple Organ D Resuscitated Porcine Progressive Sepsis. Crit Care Med 2019 (Epub ahead of print) • Chvojka J, Martinkova V, Benes J, Valesova L, Danihel V, Nalos L, Matejovic M. Mechanica Support in Refractory Vasodilatory Septic Shock: A Randomized Controlled Porcine Study. ahead of print) • Paskova V, Medvecky M, Skalova A, Chudejova K, Bitar I, Jakubu V, Bergerova T, Zemlickov Papagiannitsis CC, Hrabak J. Characterization of NDM-Encoding Plasmids From Enterobacter From Czech Hospitals. Front Microbiol. 2018; 9:1549. • Kukla R, Chudejova K, Papagiannitsis CC, Medvecky M, Habalova K, Hobzova L, Bolehovska R Hrabak J, Zemlickova H. Characterization of KPC-Encoding Plasmids from Enterobacteriacea Czech Hospital. Antimicrob Agents Chemother. 2018; 62(3). pii: e02152-17. • Skalova A, Chudejova K, Rotova V, Medvecky M, Studentova V, Chudackova E, Lavicka P, Ber V, Zemlickova H, Papagiannitsis CC, Hrabak J. Molecular Characterization of OXA-48-Like- Enterobacteriaceae in the Czech Republic and Evidence for Horizontal Transfer of pOXA-48 Antimicrob Agents Chemother. 2017; 61(2). pii: e01889-16. • Jarkovska D, Markova M, Horak J, Nalos L, Benes J, Al-Obeidallah M, Tuma Z, Sviglerova J Matejovic M, Stengl M. Cellular Mechanisms of Myocardial Depression in Porcine Septic Sh Physiol 2018; 9:726 • Jarkovska D, Valesova L, Chvojka J, Benes J, Danihel V, Sviglerova J, Nalos L, Matejovic Heart-rate variability depression in porcine peritonitis-induced sepsis without organ fa Med 2017; 242:1005-1012 • Matejovic M, Valesova L, Benes J, Sykora R, Hrstka R, Chvojka J. Molecular differences i of the kidney to sepsis-induced kidney injury. BMC Nephrol 2017; 18:183 • Jarkovska D, Valesova L, Chvojka J, Benes J, Sviglerova J, Florova B, Nalos L, Matejovic Heart Rate Variability in Porcine Progressive Peritonitis-Induced Sepsis. Front Physiol • Matejovic M, Ince C, Chawla LS, Blantz R, Molitoris BA, Rosner MH, Okusa MD, Kellum JA, XIII Work Group. Renal Hemodynamics in AKI: In Search of New Treatment Targets. J Am Soc 27:49-58 •