Iron catalyzed N-methylation of amine hydrogenation
Faculty of Science
Servier Research Institute of Medicinal Chem Carbon dioxide (CO?) utilization in chemical reactions plays a significant role in advanci technologies and represents a promising approach to the sustainable consumption of this gr Despite being a thermodynamically stable molecule, its excessive emission necessitates its value-added products to mitigate environmental impact. N-methylated compounds are importan motifs contained in natural products and industrial chemicals, such as agrochemicals, lubr surfactants, and pharmaceuticals. Traditional methods for methylation of amines involve th reagents and precious transition metals (ruthenium, palladium, platinum), thereby making t unsustainable. The development of a robust and sustainable N-methylating strategy that wil use of CO2 as the C1 building block and catalyzed by earth-abundant and environmentally be complexes is the main goal of the current proposal. Hydrogen gas will be employed as the r approach will ensure the formation of the products with high atom economies and with water product. The aims of the project involve the synthesis of the complexes with suitable liga application in the N-methylation reaction. In collaboration with our pharmaceutical indust (SERVIER), we aim to develop green and scalable methods for the N-methylation of amines, a structural motif in many active pharmaceutical ingredients. This sustainable approach for pharmaceuticals addresses several United Nations Sustainable Development Goals (SDGs), nam Health and Well-being), SDG 12 (Responsible Consumption and Production), and SDG 13 (Clima
Sustainable Development Go Meet the Project If you had to explain your project to someone outside your field, how would you describe i sentences? My project proposal focuses on using carbon dioxide (CO?) as a building block rather than as a waste. CO2 is a greenhouse gas, causing environmental issues, but it contains carbon, which also building block of organic compounds, such as many pharmaceuticals. We would like to study of incorporating the carbon-dioxide derived carbon into high value chemicals, such as phar this way, we would not only avoid its cumulation in the atmosphere, but we would turn it i useful and valuable. If the proposed plan works, then it sets a new benchmark for green chemistry, a sustainabl chemicals, eliminates waste generation, and contributes to carbon management efforts. What fascinates you most about the topic of your research project? My research proposal focuses on rethinking CO? not just as a problem, but as an opportunit just seeing it as a greenhouse gas, this project looks at how we can use it as a building valuable chemicals, which feels both exciting and meaningful. I also find it really intere a benign and biocompatible metal, can be used as a catalyst for this transformation. What is that the N-methylated amines are important synthons for pharmaceuticals, so how we make sustainable way could have real-world impact. It makes the project feel relevant, not just interesting. How does your research contribute specifically to achieving the UN Sustainable Development The present research proposal is focused on the reduction of CO? and the synthesis of indu important methylated amines. The proposed research contributes to different United Nations Sustainable Development Goal (Good Health and Well-Being), SDG 12 (Responsible Consumption and Production), and SDG 13 by developing a catalytic methodology to utilize CO? for the synthesis of methylated amine intermediates in pharmaceuticals and agrochemicals. By converting CO? (greenhouse gas) into value-added chemicals, this research supports carb and utilization (CCU) strategies and contributes to the reduction of net emissions of CO2, circular carbon economy. The process emphasizes atom economy and the use of renewable starting materials. Compared synthesis routes for methylated amines, this approach minimizes waste and reduces dependen renewable resources. This aligns with the transition toward greener route. Methylated amines are essential building blocks in the synthesis of many active pharmaceut (APIs). By enabling a more sustainable and potentially less toxic production route, this r indirectly contributes to safer pharmaceutical manufacturing. This can reduce environmenta and exposure to hazardous chemicals therfore improving public health outcomes.
N.B. Funded by the European Union. Views and o are however those of the author(s) only and do not necessarily reflect those of the Europe European Research Executive Agency. Neither the European Union nor the granting authority responsible for them.