List of Post-Doctoral Fellowships ****************************************************************************************** * A new call for applications has been announced ! ****************************************************************************************** Applicants can apply in 2023 for positions in projects announced by following faculties / 1.First Faculty of Medicine : 2 projects 2.Faculty of Education : 4 projects 3.Faculty of Arts : 3 projects 4.Faculty of Humanities : 3 projects 5.Faculty of Social Sciences : 3 projects 6.Faculty of Mathematics and Physics : 5 projects 7.Faculty of Science : 8 projects 8.Faculty of Law : 10 projects 9.Faculty of Medicine in Pilsen : 2 projects 10Faculty of Pharmacy in Hradec Králové : 2 projects Deadlines of submitting of applications you will find under each specific project. More de information about general conditions of applying for positions funded by JUNIOR Fund you c website: JUNIOR Fund (Post-doc) [ URL "https://cuni.cz/UKEN-178.html"] . ****************************************************************************************** * First Faculty of Medicine ****************************************************************************************** |1| Title of the research project: IMPROVING LABORATORY DIAGNOSTICS OF NEURODEGENERATIVE DISEASES BY SEED AMPLIFICATIO Description: Number of people suffering from neurodegenerative diseases, like Alzheimer and Parkinson d quickly increasing. The available treatment options are limited and the cost of care for t massive. Early diagnosis of neurodegenerative diseases is difficult, and the rate of misdi in specialized centres. There is a pressing need to find reliable biomarkers allowing conf diagnosis and future population screening. Neurodegenerative diseases are defined by depos misfolded proteins in the brain tissue. Harnessing prion like activity of these pathologic proteins for their detection by seed amplification assay is one of the most promising diag (1). The misfolded protein in patient sample triggers misfolding and aggregation of recomb substrate which is detected in real time using fluorescent probe. The assay was originally detection of prions, but its variants for other amyloid forming proteins like alpha synucl are being developed by different laboratories around the globe. Our laboratory was first t QuIC assay for detection of prions (2) in Visegrad countries and we are now exploring the RT-QuIC assay for detection of other pathologically folded proteins. One of the outstandin if the aggregated products of the seed amplification assays carry the information about th of original pathological seeds (3) and if this information can be used to improve the assa potential. The proposed project is aiming to investigate structural fidelity of amyloid ag utilizing prion and alpha synuclein RT-QuIC assays, various recombinant substrates, well d seeds and different assay conditions. Structural studies utilizing proteomic and spectrosc be carried out in collaboration with expert groups at Czech Academy of Science and patient from collaborating Neurology clinic and National reference laboratory for human prion dise References: 1. Vascellari S, Orr? CD, Caughey B. Real-Time Quaking- Induced Conversion Assays for Prio Synucleinopathies, and Tauopathies. Front Aging Neurosci. 2022 Mar 10;14:853050. 2. Moško T, Galušková S, Matěj R, Brůžová M, Holada K. Detection of Prions in Brain Homoge Samples Using a Second-Generation RT-QuIC Assay: A Useful Tool for Retrospective Analysis Samples. Pathogens. 2021 Jun 13;10(6):750. 3. Standke HG, Kraus A. Seed amplification and RT-QuIC assays to investigate protein seed strains. Cell Tissue Res. 2023 Apr;392(1):323-335. doi: 10.1007/s00441-022-03595-z. Qualifications: • Ph.D. in neurosciences, cell biology, biochemistry or equivalent. • Prior experience with molecular biology method, recombinant protein purification and pro research will be appreciated. Workplace/Institution: Institute of Immunology and Microbiology, First Faculty of Medicine University and General University Hospital in Prague Supervisor: Assoc. Prof. Karel Holada, Ph.D. E-mail of the supervisor: karel.holada(zavinac)lf1.cuni.cz [ MAIL "karel.holada(zavinac)lf Position available from: January 1, 2024 Deadline date for applications: July 21, 2023 Applicants must submit required documents [ URL "https://cuni.cz/UKEN-178.html#10"] to: An anna.jezberova(zavinac)lf1.cuni.cz [ MAIL "anna.jezberova(zavinac)lf1.cuni.cz"] _____________________________________________________________________________ |2| Title of the research project: INVESTIGATING THE EFFICACY OF BEHAVIOURAL SPEECH THERAPY IN PARKINSON’S DISEASE PAT Description: Deep brain stimulation of the subthalamic nucleus (STN-DBS) is an effective treatment of m of Parkinson’s disease (PD), but its effects on speech are equivocal. Although some aspect might improve with STN-DBS, stimulation-induced dysarthria represents the most common side prevalence of up to 90% (Krack et al. 2003). Recently, the effectiveness of new behavioral called SPEAK OUT!® has been demonstrated in group of PD patients treated with antiparkinso (Behrman et al. 2020). This therapy is based on principles of motor learning, where patien convert speech from an automatic function to an intentional once. Compared to most popular speech therapy ‘Lee Silverman Voice Treatment‘, which focuses mainly on improvement of voc SPEAK OUT® program aims to increase patient’s awareness of breath support, enhance their c between the respiratory and laryngeal systems, improve vocal intensity, and refine speech cognition, and conversation abilities (Behrman et al. 2020). The effectiveness of SPEAK OU therapy in PD patients with STN-DBS has never been investigated (Tripoliti et al. 2011). T main aim of the study is to evaluate the effectiveness and suitability of SPEAK OUT® thera DBS PD patients compared to dopaminergic medication only treated PD. The other aims of the to assess the minimum number of repetition for short vocal tasks required to obtain the re acoustic assessment of speech performance and to provide new acoustic methods necessary fo speech therapy in PD (Kryze et al. 2021; Rusz et al. 2021). The choice of suitable speech patients to regain and retain their speech and communication skills while minimizing swall therefore improve their quality of life. Thus, the objectives of the proposed Junior project will be to 1) evaluate the effectivene suitability of SPEAK OUT speech therapy in STN-DBS PD patients compared to dopaminergic me treated PD; 2) assess the minimum number of repetition for short functional vocal tasks (i phonation and syllable repetition) required to obtain the representative acoustic assessme performance necessary for feedback during speech therapy in PD; 3) to provide new acoustic for feedback during speech therapy in PD. References: Behrman A, Cody J, Elandary S, Flom P, Chitnis S. The Effect of SPEAK OUT! and The LOUD Cr Dysarthria Due to Parkinson's Disease. Am J Speech Lang Pathol. 2020 Aug 4;29(3):1448-1465 10.1044/2020_AJSLP-19-00024. Krack P, Batir A, Van Blercom N et al. Five-year follow-up of bilateral stimulation of the nucleus in advanced Parkinson's disease. N Engl J Med 2003; 349: 1925-1934. Krýže P, Tykalová T, Růžička E, Rusz J. Effect of reading passage length on quantitative a assessment in Czech-speaking individuals with Parkinson's disease treated with subthalamic brain stimulation. J Acoust Soc Am. 2021 May;149(5):3366. doi: 10.1121/10.0005050. Rusz J, Tykalova T, Ramig LO, Tripoliti E. Guidelines for Speech Recording and Acoustic An Dysarthrias of Movement Disorders. Mov Disord. 2021 Apr;36(4):803-814. doi: 10.1002/mds.28 Tripoliti E, Strong L, Hickey F, Foltynie T, Zrinzo L, Candelario J, Hariz M, Limousin P. dysarthria following subthalamic nucleus deep brain stimulation for Parkinson's disease. M Nov;26(13):2434-6. doi: 10.1002/mds.23887. Qualifications: • Ph.D. degree in biophysics with focus on speech science and therapy (defended 2019) • Ability to communicate in both spoken and written English, and at least basic Czech (to patients) • High motivation, ability to conduct collaborative research. Funding: Position will be co-financed from projects funded by the National Institute for N Research (Programme EXCELES, ID Project No. LX22NPO5107 - Funded by the European Union – N EUs). Workplace: Department of Neurology, First Faculty of Medicine, Charles University and Gene Hospital in Prague Supervisor: Assoc. Prof. Jan Rusz, Ph.D. Position available from: January 1, 2024 Deadline date for applications: July 21, 2023 Applicants must submit required documents [ URL "https://cuni.cz/UKEN-178.html#10"] to: An anna.jezberova(zavinac)lf1.cuni.cz [ MAIL "anna.jezberova(zavinac)lf1.cuni.cz"] ****************************************************************************************** * Faculty of Education ****************************************************************************************** |1| Title of the research project: FOSTERING PRE-SERVICE TEACHERS’ SCIENCE PROCESS SKILLS Science education researchers have, recently been focusing on science experiments’ role in education. Since there is a lack of evidence about experiments’ real added value in the pr students’ science process skills’ fostering are necessary to be described closer. The post topic is to map pre-service teachers’ skills when entering science laboratory as well as t improvement in reaction to common lab tasks. Their progression on the lab works will be re of cameras, later in the project eye-tracking goggles will be used too. It is expected the join the department members in their research activities, will be responsible for data col as well as its presentation and publication. Workplace: Department of Chemistry and Chemistry Education (Faculty of Education, Charles Supervisor: doc. PhDr. Martin Rusek, Ph.D. E-mail: martin.rusek(zavinac)pedf.cuni.cz [ MAIL "martin.rusek(zavinac)pedf.cuni.cz "] Position available from: January 1, 2024 Deadline date for applications: July 31, 2023 Applicants must submit required documents [ URL "https://cuni.cz/UKEN-178.html#10"] to: El eliska.smerdova(zavinac)pedf.cuni.cz [ MAIL "eliska.smerdova(zavinac)pedf.cuni.cz"] (facul the Junior Fund) _____________________________________________________________________________ |2| Title of the research project: PEDAGOGICALLY PRODUCTIVE TALK AMONG UNIVERSITY TEACHERS: LEARNING THROUGH DIALOGIE The Department of Pre-Primary and Primary Education in the Faculty of Education offers a p position in the area of research on pedagogically productive conversation among university their learning through dialogue. The research focuses on conversations among university te examines how the concept of pedagogically productive talk is used in these conversations. productive conversation is a collaborative discourse among teachers that combines six prin involve socializing teachers into productive ways of talking and thinking about practice, reflect on and improve practice, and a commitment to student learning and teaching excelle al., 2020). The research may include both quantitative and qualitative research and target through surveys and structured interviews. Researching and improving teachers' pedagogical plays a key role, especially in improving the quality of teaching and learning in higher e (Kaynarda?, 2017), so we perceive a high relevance of the project. Workplace: Department of Pre-primary and Primary Education Supervisor: doc. PhDr. Jana Stará, Ph.D. E-mail: jana.stara(zavinac)pedf.cuni.cz [ MAIL "jana.stara(zavinac)pedf.cuni.cz"] Position available from: January 1, 2024 Deadline date for applications: July 31, 2023 Applicants must submit required documents [ URL "https://cuni.cz/UKEN-178.html#10"] to: El eliska.smerdova(zavinac)pedf.cuni.cz [ MAIL "eliska.smerdova(zavinac)pedf.cuni.cz"] (facul the Junior Fund) _____________________________________________________________________________ |3| Title of the research project: EDUCATIONAL AND SCHOOL PSYCHOLOGY The Department of Psychology is strongly focused on mechanisms of school learning and unde relevant to educational and school psychology. Our research projects focus on different gr actors (students, teachers, parents, school psychologists, etc.) and on different topics ( communication, identity, development etc.). Many students have a difficult background or get in trouble during schooling. They face a challenges related to their cognition and emotions, self-esteem, social relationships, and needs. This places also great demands on adults inside (teachers, headmasters, school coun outside the school (parents, local authorities, etc.) who need to be educated and supporte help address this challenging situation. As the Department of Psychology, we welcome proposals for postdoc projects that would suit and complement the existing research developed by our team. Proposals should seek to descr needs of schools and their actors, name critical areas, analyze their changes and formulat recommendations that would increase the effectiveness of learning and teaching. The resear can focus on students (different subgroups as socially disadvantaged, with specific cultur mentally challenged, learning disabled, gifted, etc.), teachers or parents (their attitude identities, or practices), or it can combine these groups of actors. The range of topics from current research projects at the Department of Psychology on whic projects might concentrate (but not necessarily only): - learning and metacognition - psychological factors in school success and failure - social climate in groups - parental regulation of risky behavior, e.g. overuse of digital technologies - teacher professional development, enhancing self-reflection - student well-being, belonging, and social identity - gender identity and sexual orientation - neurodiversity in education Workplace: Department of Psychology (Faculty of Education, Charles University) Supervisor: Assoc. Prof. Irena Smetáčková, Ph.D. E-mail: irena.smetackova(zavinac)pedf.cuni.cz [ MAIL "irena.smetackova(zavinac)pedf.cuni.c Position available from: January 1, 2024 Deadline date for applications: July 31, 2023 Applicants must submit required documents [ URL "https://cuni.cz/UKEN-178.html#10"] to: El eliska.smerdova(zavinac)pedf.cuni.cz [ MAIL "eliska.smerdova(zavinac)pedf.cuni.cz"] (facul the Junior Fund) _____________________________________________________________________________ |4| Title of the research project: CONTEXTUALIZED SECONDARY DATA ANALYSIS OF INTERNATIONAL LARGE SCALE ASSESSMENT DATA International large-scale assessments (ILSAs - namely PISA, TIMSS, PIRLS, ICCs, TALIS, PIA unique source of data freely available for analysis and allowing international comparisons data requires a substantive methodological knowledge, e.g. how to work properly with compl use replication weights, properly work with plausible values, etc. We look for a post-doc and good knowledge of working with such data, ideally using Mplus or R software for multil structural equation modelling. Yet substantive quantitative knowledge needs to be backed u of educational policy and country specific information, which allows to formulate policy-r question for comparison. We offer the high knowledge of Central and Eastern European Count for analysis of policy relevant issues based on the available ILSAs data which shall be th of post-doc work. Also, data from ILSAs in post-Socialist countries are often not sufficie due to lack of researchers and methodological knowledge. The analysis could be oriented, b to, the following topics: the effects of early tracking, Big Fish Little Pond Effect, rela motivation and self-concept and achievement, socio-economic inequalities, rural-urban diff inequity, class composition and peer effects, teacher quality and teacher beliefs. Applica one or two topics to specify in their post-doc application project proposal. Workplace: Institute for Research and Development of Education Supervisor: Dr. David Greger E-mail: david.greger(zavinac)pedf.cuni.cz [ MAIL "david.greger(zavinac)pedf.cuni.cz"] Position available from: January 1, 2024 Deadline date for applications: July 31, 2023 Applicants must submit required documents [ URL "https://cuni.cz/UKEN-178.html#10"] to: El eliska.smerdova(zavinac)pedf.cuni.cz [ MAIL "eliska.smerdova(zavinac)pedf.cuni.cz"] (facul the Junior Fund) ****************************************************************************************** * Faculty of Arts ****************************************************************************************** |1| Title of the research project: TOWARDS A CONTRASTIVE FUNCTIONAL GRAMMAR FOR NON-NATIVE LEARNERS: TACKLING THE FUNC Description of the project: The Institute of Czech Studies is seeking a highly qualified international post-doc resear field of linguistics and/or Czech/Slavic Studies. The researcher is expected to focus on t framework for comparative functional grammar for non-native learners of Czech and Polish. task will be description of grammatical means in terms of their communicative functions. T should be ready to take part in the activities and ongoing projects of the Institute, espe organisation of workshops and conferences in 2024. The successful candidate is expected to carry out independent research and teach two cours in English. At the level of the research, the researcher is expected to publish at least o article in a database journal during the project. Moreover, by the end of the project, the candidate will be encouraged to apply for a research grant (to be further discussed with t institution) to continue our collaboration. What do we offer? • Teaching opportunities in relevant courses; • The post includes a two-year contract in Prague (i.e., 2024 and 2025) under competitive conditions; • Training in using corpus methods in analysis. Profile of an ideal candidate: • Ph.D. degree in linguistics, corpus linguistics or Czech/Slavic studies (less than 5 yea graduation) • Research interest and publication track record particularly in the field of linguistics Studies • Strong background in linguistics and Czech/Slavic studies • Teaching experience is welcome • Excellent knowledge of English (FCE equivalent or better) • Strong research skills, creativity, motivation and ability to participate in large resea • Due to tax specification, the candidate cannot be employed in any other country than Cze course of the postdoctoral period The applicants should submit: • All documents [ URL "https://cuni.cz/UKEN-178.html#10"] required by the Charles Universi • Research proposal (max. 5 standard pages) • Sample syllabi of two proposed courses/seminars Salary: Equivalent to 2000 EUR/month Workplace: Institute of Czech Studies (Faculty of Arts, Charles University): https://ubs.f [ URL "https://ubs.ff.cuni.cz/cs/"] Supervisor: Mgr. Adrian Jan Zasina, Ph.D. (Head of the Institute) Contact: adrian.zasina(zavinac)ff.cuni.cz [ MAIL "adrian.zasina(zavinac)ff.cuni.cz"] Phone: +420 221 619 262 Position available from: January 1, 2024 Deadline for applications: July 9, 2023 Applicants must submit required documents to: adrian.zasina@ff.cuni.cz [ URL "mailto:adrian.zasina@ff.cuni.cz"] (project supervisior) _____________________________________________________________________________ |2| Title of the research project: GERMAN LITERATURE OF BOHEMIAN LANDS IN INTERCULTURAL AND SPATIAL PERSPECTIVE Description of the project: Department of Germanic Studies is seeking a qualified post-doctoral researcher oriented to quality research in history of German literature and culture  of the Bohemian Lands. Research on German literature and culture in the Czech lands has recently gained new impul the access to some important, previously unprocessed archival collections, the methodologi potential of digital humanities and the application of current theoretical concepts of div (intercultural theory; translation studies; field theory; network theory; media theory; po studies, regional studies or interdisciplinary Jewish studies). As a result, today's resea of the national philological models of literary and scientific history and is open to obse that only become apparent when looking at the context of the Central European cultural "me Understanding these historical phenomena contributes to the understanding of cultural clas of cultural balancing in the present. The project is expected to focus on the topics that form part of aforementioned recent cha theoretical reflection and overall design of this research area. The researcher is expecte least one high-quality article in a database-indexed journal per academic year, actively c the researchers from the Kurt Krolop Centre for German Literature in Bohemia, and take par the Department of Germanic Studies with one course per semester. What do we offer? • The post includes a two-year contract in Prague (i.e., 2024 and 2025) under competitive conditions; • Participation in the ongoing projects of the Centre and the Department (including intern conferences dedicated to Franz Kafka and R. M. Rilke); • Teaching opportunities in relevant courses. Profile of an ideal candidate: • Completed Ph.D degree (max. 5 years since its award); • Excellent command of German and English; • Strong background in history of literature and culture of the Bohemian Lands and either sociology/comparative politics, or discourse analysis/cultural studies; • Ability to carry out collaborative research; • Teaching experience is welcome; • (Due to tax specification, the candidate cannot be employed in any other country than th in course of the postdoctoral period.) The applicants should submit: • All documents [ URL "https://cuni.cz/UKEN-178.html#10"] required by the Charles Universi • Research proposal (max. 5 standard pages) • Sample syllabus of one proposed course/seminar Salary: Equivalent to 2000 EUR/month Workplace: Department of Germanic Studies Supervisor: Štěpán Zbytovský, Ph.D. E-mail: stepan.zbytovsky(zavinac)ff.cuni.cz [ MAIL "stepan.zbytovsky(zavinac)ff.cuni.cz "] Phone:+420 221 619 244 Position available from: January 1, 2024 (for 24 months) Deadline date for applications: July 16, 2023 Applicants must submit required documents to: stepan.zbytovsky(zavinac)ff.cuni.cz [ MAIL "stepan.zbytovsky(zavinac)ff.cuni.cz "] _____________________________________________________________________________ |3| Title of the research project: MEDIEVAL STUDIES Description of the project: The Centre for the Study of the Middle Ages is seeking a highly qualified international po who would join the interdisciplinary team of medievalists at the Centre for two years. Any topic in the field of Medieval Studies is welcome. In addition to pursuing his or her own the researcher will take active part in the Centre?s endeavors. Based on his or her field, will be integrated into the relevant department of the Faculty of Arts, and will be expect in the activities of the department, too. What do we offer? • The post includes a two-year contract in Prague (i.e., 2024 and 2025) • Participation in the ongoing projects of the Centre for the Study of the Middle Ages (cu "https://css.ff.cuni.cz/?lang=en"] • Teaching opportunities in relevant courses • Training in Digital Humanities connected to the project work Profile of an ideal candidate: • Ph.D. degree in field relevant for Medieval Studies such as medieval history, philosophy languages, latin studies, art history, archaeology, musicology etc. (less than 5 years s • Research interest and publication track record • Experience in Digital Humanities is welcome • Teaching experience is welcome • Excellent knowledge of English (FCE equivalent or better) • Strong research skills, creativity, motivation and ability to participate in large resea Due to tax specification, the candidate cannot be employed in any other country than Czech course of the postdoctoral period. The applicants should submit: • All documents [ URL "https://cuni.cz/UKEN-178.html#10"] required by the Charles Universi • Research proposal (max. 5 standard pages) • Sample syllabi of two proposed courses/seminars Salary: Equivalent to 2,000 EUR/month Workplace: Faculty of Arts Supervisor: Prof. Mgr. Lucie Doležalová, Ph.D. / Doc. PhDr. Tomáš Klír, Ph.D. E-mail: lucie.dolezalova(zavinac)ff.cuni.cz [ MAIL "lucie.dolezalova(zavinac)ff.cuni.cz "] Phone: +420 605 758 079 Position available from: January 1, 2024 (for 24 months) Deadline for applications: July 15, 2023 Applicants must submit required documents to: lucie.dolezalova(zavinac)ff.cuni.cz [ MAIL "lucie.dolezalova(zavinac)ff.cuni.cz"] and tomas.klir(zavinac)ff.cuni.cz [ MAIL "tomas.klir(zavinac)ff.cuni.cz"] _____________________________________________________________________________ |4| Title of the research project: IDEOLOGY AND ILUSIONS. RUSSIAN AND SOVIET IMPACT ON THE CZECH AND CZECHOSLOVAK CULT CENTURY Description of the project: Institute of Czech and Comapartive Literature is seeking a qualified post-doctoral researc towards high quality research in the field of Czech and Comapartive Literture. We list the postdoc's position out of the need to describe the newly Czech literary space coordinates of the historical tension between Slavic and German. This new description shou new archival research, both on the sources of Slavic emigration in Czechoslovakia between research into the archives of the state security, irreplaceable for the period after the c 1948. Nowadays, in order to understand Russian and Soviet influence in our country, it is necess the long shadows of ideologies and illusions, and especially illusions about our Slavicnes Russia, which accompanied Czech literature and culture throughout the 19th and 20th centur it is necessary to restore the distorted memory of non-Russian Slavic cultures and literat goals, it is necessary to turn to new methods and to current theoretical concepts of diver (intercultural theory; translation studies; field theory; network theory; media theory; po studies, regional studies). This is in accordance with the two lines of literary historica institute, which focus on the culture of the 19th century and the first half of the 20th c other hand, on the period after the communist takeover. Requirements for the researcher: the researcher should be a comparatist, a Slavist who is Germanically oriented. He/she should be able to use the new possibilities of digital human his/her focus should be primarily philosophical-aesthetic, sociological and literary-histo ability to work through ideologies as formative constructs that have shaped cultures and i mainly in the long 19th century and the short 20th century is absolutely essential. The researcher is expected to publish at least one high-quality article in a database jour year, actively collaborate with the researchers from the sucesfull team of literary histor part in teaching at the Institute of Czech anad Comparative literature with one course per What do we offer? • The post includes a two-year contract in Prague (i.e., 2024 and 2025) under competitive conditions; • Participation in the ongoing projects of the Centre and the Department (including two in conferences dedicated to „Dmitro Čiževsky and Ukranian and Russian Emigration in Czechoslo heritage“ and „Masculinities in Central Europe“); • Teaching opportunities in relevant courses. Profile of an ideal candidate: • Completed Ph.D degree (max. 5 years since its award); • Excellent command of German, Russian and English, good Czech and Slovak; • Strong background in history of literature and culture of the Bohemian Lands and either sociology/comparativeesthetics, or discourse analysis/cultural studies; • Ability to carry out collaborative research; • Teaching experience is welcome. Due to tax specification, the candidate cannot be employed in any other country than Czech course of the postdoctoral period. The applicants should submit: • All documents [ URL "https://cuni.cz/UKEN-178.html#10"] required by the Charles Universi • Research proposal (max. 5 standard pages) • Sample syllabus of one proposed course/seminar Salary: Equivalent to 2000 EUR/month Workplace: Institute of Czech and Comparative Literature Contact: Doc. Mgr. Libuše Heczková, PhD. E-mail: libuse.heczkova(zavinac)ff.cuni.cz [ MAIL "libuse.heczkova(zavinac)ff.cuni.cz"] Phone: +420 221 619 232 Position available from: January 1, 2024 Deadline for applications: July 16, 2023 Applicants must submit required documents [ URL "https://cuni.cz/UKEN-178.html#10"] to: libuse.heczkova(zavinac)ff.cuni.cz [ MAIL "libuse.heczkova(zavinac)ff.cuni.cz"] ****************************************************************************************** * Faculty of Humanities ****************************************************************************************** |1| Title of the research project: VOLUNTEERING, VOLUNTARY CITIZEN ACTION AND CIVIL SOCIETY MOBILIZATION AT TIMES OF C The Department of Sociology at the Faculty of Humanities invites applications for a postdo in the research area of volunteering, voluntary citizen action and civil society mobilizat crisis. During the Covid-19 pandemic, governments, citizens, nonprofit organizations and other soc deal with an unprecedented situation. The ways societies and governments have handled the are likely to have social, political and ethical impacts and may have become part of the n Volunteering during the crisis has received immediate academic attention but the volunteer conflicting expectations and forms of volunteering during the pandemic (and during the war yet to be explored. We invite research on the shifting meanings and practice of volunteering as voluntary unpa public sphere during societal crisis in general. Social expectation about volunteers' role or value of their work are not well settled even in countries with long and uninterrupted volunteering, such as the UK or US. This uncertainty of meanings of volunteering is even m countries such as the Czech Republic, where the present day tradition of formal organized not started before mid-1990s. The research may focus on volunteering in social and health care services during the pande and informal voluntary unpaid help during the war in Ukraine, critical issues concerning t abuses of volunteering by governments and nonprofit organizations etc., depending on the f candidate. An ideal candidate has a PhD in sociology, social policy, social work or cultural anthropo research skills and a proven ability to conduct research at a post-doctoral level and publ international journals. Our department has an experience with Fullbright Fellows and we lo working together with a new colleague. Expected outcomes of the post-doctoral fellowship i quality journal article (Jsc or Jimp), collaboration on a new research project with other department, partial involvement in the training of doctoral or graduate students. We would the candidate can enrich the international dimension of our faculty by co-organizing an in workshop in the area of her/his expertize. Faculty: Faculty of Humanities Department: Department of Sociology Supervisor: doc. PhDr. Tereza Pospíšilová, Ph.D. E-mail: tereza.pospisilova(zavinac)fhs.cuni.cz [ MAIL "tereza.pospisilova(zavinac)fhs.cuni Deadline date: July 19, 2023 Position available from: January 1, 2024 Submit applications with all other documents [ URL "https://cuni.cz/UKEN-178.html#10"] to Research Administration Office: veda(zavinac)fhs.cuni.cz [ MAIL "veda(zavinac)fhs.cuni.cz" tereza.pospisilova(zavinac)fhs.cuni.cz [ MAIL "tereza.pospisilova(zavinac)fhs.cuni.cz"] ) _____________________________________________________________________________ |2| Title of the research project: DEFINING HUMAN ORGASMS AND ORGASM DISORDERS Orgasm is a complex, multimodal reflex induced typically by genital stimulation and coming of the sexual response cycle, prior to the inhibition that characterizes sexual refractori Johnson originally described a singular orgasm pattern for men, but three distinct pattern result has been replicated using a variety of objective physiological measures. Mechanisti stimulation activates excitatory neurochemical pathways in the brain and spinal cord that stimulate sympathetic outflow and the inhibition of parasympathetic spinal circuits in the cord to induce the feeling of release that characterizes climax (and ejaculation in males) spinal inhibition. At the same time, the conscious awareness of orgasm occurs as a rush of pleasure due to the release of endogenous opioids in the brain, followed by a feeling of s relaxation due to the release of serotonin and other neurochemicals. In men orgasm and cli consonant with ejaculation, which is typically achieved by stimulation of the glans and sh In women, climax and orgasm are typically achieved by stimulation of the external glans of Some women can also achieve qualitatively different orgasms by stimulation of the internal of clitoris and paraurethral glands (prostate) that are known collectively and colloquiall spot”. Orgasms can also be achieved by stimulation of the anterior cervix and even by inte of the nipples and other erogenous zones in sensitized individuals. Although the reflex is “bottom-up” genitosensory stimulation, it is also controlled by “top-down” processing of e inhibition that controls both the timing of parasympathetic and sympathetic blood flow, an ability to “let go” into the orgasm when it is imminent. Indeed, orgasms activate cortical hypothalamic, and brainstem structures, and can be rated psychologically in terms of the p and quality of sensory stimulation, affective experience, and the evaluation of pleasure. accompanied reliably by reflexive activation of pelvic floor muscles along with changes fa and arm, leg, and toe flexions. This motor activation induces movement artifacts reflected activation and patterns of electrical activity in the cortex that are difficult to control orgasms are also accompanied by neurochemical and endocrine changes that characterize both state of pleasure and longer-term inhibition (refractoriness). Among these correlates is a orgasm-induced surge of prolactin released from the anterior pituitary into the peripheral   Among the sexual dysfunctions, orgasm disorders affect 25% to 40% of women and men, depend sexual experience. These include anorgasmia, delayed ejaculation/orgasm, anhedonic orgasm release without pleasure), and post-orgasmic illness syndrome (fever, illness, and inflamm likely due to a high sensitivity to histamine released from mast cells at orgasm). Men can early or rapid ejaculation that is under chronically disinhibited control. Most people wit disorders experience moderate to intense distress, and the incidence of orgasm disorders i age. According to both the DSM-5 and the ICD-11, orgasm disorders can be lifelong or acqui or situational, and organic or multifactorial, with the latter being due to medications th or abolish orgasm, like major tranquilizers, antihypertensives, opioid antagonists, anxiol antidepressants, especially the selective serotonin reuptake inhibitors (SSRIs), such as f Indeed, because of their mechanism of action, SSRIs are often used off-label to treat rapi But despite growing knowledge, there are still many outstanding questions regarding orgasm orgasms and orgasm disorders be detected objectively and subjectively in females and males differences between different orgasms obtained through different kinds of genitosensory or stimulation, or by masturbation versus sex with a partner?  What are the effects of orgasm and relationship satisfaction?  And what contributes to the “orgasm gap” between females a questions are at the forefront of sexual medicine today, and especially among sexual minor We currently offer a Postdoc position where the candidate will focus on assessing the subj orgasms in sexual and relationship satisfaction using standardized measures like the Orgas of Mah and Binik, and the effect of orgasms on quality of sleep, using standardized sleep in females and males without orgasm disorders, and in clinical populations of females and disorders. Data will be derived from both heteronormative cis-gendered individuals and fro sexual minorities within the LGBTIQA2+ communities. The candidate would also participate i of anonymized pelvic floor orgasm data from females using the Lioness biofeedback vibrator study, and from males using a new biofeedback tool being developed by Tenga. The candidate these data in cooperation with the National Institute of Mental Health. She or he will als suggest and organize follow up studies. Specific requirements set by the Department of Psychology and Life Sciences FHS UK: We expect that our new research colleague will be able to work independently and will brin and ideas to our team. She or he should have reasonable experience with the advanced techn quantitative and qualitative methods of psychology-related data obtained from questionnair psychophysiological measurements. Experience with the analysis of brain and hormonal sampl as we will likely be assessing plasma prolactin in future studies. Faculty: Faculty of Humanities Department: Department of Psychology and Life Sciences Supervisor: RNDr. James G. Pfaus, Ph.D. E-mail: jim.pfaus(zavinac)fhs.cuni.cz [ MAIL "jim.pfaus(zavinac)fhs.cuni.cz "] Deadline date: July 19, 2023 Position available from: January 1, 2024 Submit applications with all other documents [ URL "https://cuni.cz/UKEN-178.html#10"] to Research Administration Office: veda(zavinac)fhs.cuni.cz [ MAIL "veda(zavinac)fhs.cuni.cz" jim.pfaus(zavinac)fhs.cuni.cz [ MAIL "jim.pfaus(zavinac)fhs.cuni.cz "] ) _____________________________________________________________________________ |3| Title of the research project: THE ANTHROPOLOGY OF ARTIFICIAL INTELLIGENCE We invite applications for a postdoctoral researcher position specializing in the anthropo artificial intelligence (AI) at the Faculty of Humanities, Charles University, located in of Prague. This position offers the opportunity to join a young, dynamic, and interdiscipl the recently founded AI Institutional Transformation Research Group [ URL "https://www.ins transformation.org/home"] . About the Field: The anthropology of AI is a burgeoning field within social-cultural anthr focuses on understanding the social and cultural dimensions of AI technology across divers interdisciplinary field blends qualitative research methods, particularly ethnography, wit perspectives from other disciplines, such as computer science, philosophy, or sociology. Project Scope: The successful candidate will conduct a project to investigate the influenc institutional transformations, focusing specifically on how AI systems shape social dynami relations, and cultural practices within institutions. The project aims to provide in-dept empirical evidence of how AI technologies impact institutional frameworks. Ethical aspects as fairness, transparency, and equitable distribution of benefits and risks, will be integ research. Candidate Profile: We seek a candidate with a Ph.D. in social/cultural anthropology, ethno studies, or sociology. The candidate should have a strong background in social/cultural an and experience in anthropological fieldwork, including online and offline ethnography. Pre specializations include digital anthropology and/or science and technology studies (STS), by a publication track record. A working knowledge of AI technology and its applications i is expected. Previous teaching experience and excellent English skills are desired. Benefits of the Position: As a member of our team, the postdoc will gain professional deve opportunities, including publishing and presenting in high-profile venues and being involv activities (one course per semester). You will work in a collegial and supportive environm equal opportunity employer and strongly encourage applications from underrepresented group are committed to fostering a diverse and inclusive academic community. Faculty: Faculty of Humanities Department: Department of Social and Cultural Anthropology Supervisor: Mgr. Martin Heřmanský, Ph.D. E-mail: martin.hermansky(zavinac)fhs.cuni.cz [ MAIL "martin.hermansky(zavinac)fhs.cuni.cz Deadline date: July 19, 2023 Position available from: January 1, 2024 Submit applications with all other documents [ URL "https://cuni.cz/UKEN-178.html#10"] to Research Administration Office: veda(zavinac)fhs.cuni.cz [ MAIL "veda(zavinac)fhs.cuni.cz" martin.hermansky(zavinac)fhs.cuni.cz [ MAIL "martin.hermansky(zavinac)fhs.cuni.cz"] ) ****************************************************************************************** * Faculty of Social Sciences ****************************************************************************************** |1| Title of the research project: SETTING SUSTAINABLE DEVELOPMENT PRINCIPLES IN COMMUNICATION Institute of Communication Studies and Journalism at Charles University seeks a post-docto the field of Sustainability and marketing communication. The candidate is expected to exhi of-records linked to one of the following topics: Sustainability in business, marketing co Sustainability. We are looking for an innovative scholar with the potential to bridge the communication, business, and sustainability domains. The expected outcome of the fellowship is two journal articles (Jsc or Jimp) and involveme training. Upon further agreement, post-doctoral fellows will also have an opportunity to b teaching. Workplace: Institute of Communication Studies and Journalism (Faculty of Social Sciences, University) Supervisor: Ing. Petra Koudelková, Ph.D. E-mail: petra.koudelkova(zavinac)fsv.cuni.cz [ MAIL "petra.koudelkova(zavinac)fsv.cuni.cz" Position available from: January 1, 2024 (24 months) Deadline for applications: July 21, 2023 Applicants must submit required documents [ URL "https://cuni.cz/UKEN-178.html#10"] to: petra.koudelkova(zavinac)fsv.cuni.cz [ MAIL "petra.koudelkova(zavinac)fsv.cuni.cz"] _____________________________________________________________________________ |2| Title of the research project: INTERNATIONAL RELATIONS IN THE TIME OF UNCERTAINTY During several previous decades, world politics rested on an evolving, but still rather pe of an international order. This order was to a large extent based on the dominant position States (USA). Yet it also involved several important normative elements, represented by li intensive global economic cooperation, or international institutions. To a high extent, th was sustained by the demand coming from the other states, which saw it as an enabling arra dealing with global problems such the spread of weapons of mass destruction, terrorism, gl crises, or environmental degradation.  At this moment, this order that has so far characterized international politics is facing challenges. One of the factors that weaken it is the changing distribution of power in the system, marked by the decreasing position of the USA and the strengthening of the so-calle Furthermore, developing countries often hold different views about the appropriate form of order, putting a greater emphasis on the principles of sovereignty and justice. Simultaneo the turbulent development can be attributed to social and ideological changes taking place countries. Last but not least, Russia’s invasion of Ukraine challenges the basic respect f of collective security.  Within this topic, we are searching for a post-doc candidate that would identify and explo issue that has to do with the contemporary transformative processes in international polit candidate should definitely dispose with a strong theoretical and methodological backgroun background should enable him/her to contribute to the international academic debates. As f research topic, we are rather flexible. The concrete topic would need to be in some way co changing characteristics of world politics. In this context, we welcome proposals that may cooperative, as well as conflictual aspects of world politics. In terms of issue areas, we consider proposals that may be concerned with security issues, international economic rela other substantive field of the contemporary international relations.   Workplace: Institute of Political Studies (Faculty of Social Sciences, Charles University) Supervisor: doc. PhDr. Jan Karlas, Ph.D. Email: jan.karlas(zavinac)fsv.cuni.cz [ MAIL " jan.karlas(zavinac)fsv.cuni.cz"] Position available from: January 1, 2024 (24 months) Deadline for applications: July 21, 2023 Applicants must submit required documents [ URL "https://cuni.cz/UKEN-178.html#10"] to jan.karlas(zavinac)fsv.cuni.cz [ MAIL " jan.karlas(zavinac)fsv.cuni.cz"] _____________________________________________________________________________ |3| Title of the research project: DISINFORMATION, THE ROLE OF MEDIA AND AUDIENCES Institute of Communication Studies and Journalism invites international post-docs to apply journalism studies with an emphasis on the role of misinformation in the public space and functioning of the media. The successful candidate will become part of a dynamic team work both in research (the team is currently focusing among other projects on the Horizon grant for Democracy in the Digital Age) and in teaching at the Department of Journalism. The top link the role of media and audiences and focus on political communication, what role disin in contemporary democratic systems, and how modern liberal democracies can defend themselv Expected outcomes of the post-doctoral fellowship include: • Two high-quality journal articles (Jimp) • Involvement in the training of Ph.D. candidates • Mutually enriching interaction with other members of the team Upon further agreement, the post-doctoral fellow will also have an opportunity to be invol activities at the Department of Journalism. Workplace: Institute of Communication Studies and Journalism (Faculty of Social Sciences, University) Supervisor: doc. PhDr. Alice Němcová Tejkalová, Ph.D. E-mail: alice.tejkalova(zavinac)fsv.cuni.cz [ MAIL "alice.tejkalova(zavinac)fsv.cuni.cz"] Position available from: January 1, 2024 (24 months) Deadline for applications: July 21, 2023 Applicants must submit required documents [ URL "https://cuni.cz/UKEN-178.html#10"] to: alice.tejkalova(zavinac)fsv.cuni.cz [ MAIL "alice.tejkalova(zavinac)fsv.cuni.cz"] ****************************************************************************************** * Faculty of Mathematics and Physics ****************************************************************************************** |1| Title of the research project: CALL FOR JUNIOR (POSTDOC) POSITION IN THE AREA OF ADVANCED TYPE SYSTEMS FOR REAL-WO Post-doc position for two-year period from 1st January 2024             Applications are invited for a postdoc position at School of Mathematics, Faculty of Mathe Physics, Charles University in Prague, Czech Republic. The position is for two years start 1, 2024. Research Project The growing importance of computer programs for economy, society and science makes it cruc that programs are constructed correctly and work as required. Static type systems are a po effective tool for writing robust and trustworthy programs. Despite being an active resear are many basic open research problems in the field. Static type systems could be used to a in a variety of different new ways, they could check for numerous kinds of currently unche while their design could be simplified and made more uniform to support their implementati programming languages. The aim of the project is to advance the state-of-the-art of static one of several directions, including, but not limited to: * How to design type systems for interactive programming environments, such as notebook sy the static type can depend on previously computed values? * How to use type systems that can guide code generation from large language models (LLMs) correctness of the generated code? * How to unify the wide range of advanced type system mechanisms such as effect systems, c ownership types, linear and uniqueness types? * How to pragmatically design usable static type systems that can check high-level logical areas such data science or low-code programming? Workplace: Department of Distributed and Dependable Systems, Malá Strana, Malostranské nám Contact person: Tomáš Petříček E-mail: petricek(zavinac)d3s.mff.cuni.cz [ MAIL "petricek(zavinac)d3s.mff.cuni.cz"] Position available from: January 1, 2024 Deadline date: July 15, 2023 Applicants should submit required documents [ URL "https://cuni.cz/UKEN-178.html#10"] to: petricek(zavinac)d3s.mff.cuni.cz [ MAIL " petricek(zavinac)d3s.mff.cuni.cz"] (project supe copy to ovzs(zavinac)dekanat.mff.cuni.cz [ MAIL "ovzs(zavinac)dekanat.mff.cuni.cz"] (facul the Junior Fund) _____________________________________________________________________________ |2| Title of the research project: CALL FOR JUNIOR (POSTDOC) POSITION IN THE AREA OF HADRON PHYSICS Post-doc position for two-year period from 1st January 2024 Applications are invited for a postdoc position at School of Mathematics, Faculty of Mathe Physics, Charles University in Prague, Czech Republic. The position is for two years start 1, 2024. Research Project The structure of hadrons is encoded in the equations of QCD. However, fifty years after th of quarks the theoretical calculations are just beginning to realistically describe their in hadrons. Precise experiments are necessary in this effort. The COMPASS experiment at CE data on semi-inclusive deep-inelastic scattering of muons off hydrogen and off transversel deuterons. The goal of our group is to analyse the data and extract the intrinsic transver the polarisation of quarks of different flavours, aiming for a 3D mapping of the nucleon i space. The new AMBER collaboration will study the proton charge radius in muon-proton scat the structure of pions and kaons in Drell-Yan process using modified COMPASS spectrometer. simulations and a new trigger-less data acquisition system with high-level data filtering The applicant is expected to contribute to these efforts at least half of the time, having devote the rest to his/her own research interests in the field. The applicants should have a Ph.D. degree in nuclear or particle physics or similar and ex the analysis of data from a nuclear or particle physics experiment (not longer than 5 year hadron physics or data acquisition systems would be welcome. He/she cannot be the holder o of the Czech Republic. Workplace: Department of Low Temperature Physics, Faculty of Mathematics and Physics, Char Holešovičkách 747/2, Prague 8 Contact person: Jan Matoušek E-mail: jan.matousek(zavinac)mff.cuni.cz [ MAIL "jan.matousek(zavinac)mff.cuni.cz"] Position available from: January 1, 2024 Deadline date: July 15, 2023 Applicants should submit required documents [ URL "https://cuni.cz/UKEN-178.html#10"] to: jan.matousek(zavinac)mff.cuni.cz [ MAIL "jan.matousek(zavinac)mff.cuni.cz"] (project super copy to ovzs(zavinac)dekanat.mff.cuni.cz [ MAIL "ovzs(zavinac)dekanat.mff.cuni.cz"] (facul the Junior Fund) _____________________________________________________________________________ |3| Title of the research project: CALL FOR JUNIOR (POSTDOC) POSITION IN THE AREA OF PURE AND APPLIED MATHEMATICS Post-doc position for two-year period from 1st January 2024 Applications are invited for a postdoc position at School of Mathematics, Faculty of Mathe Physics, Charles University in Prague, Czech Republic. The position is for two years start 1, 2024. We are looking for strong candidates in any area mathematics, including logic and algebra interpreted), number theory, geometry, harmonic analysis, functional analysis, ordinary an differential equations and dynamical systems, descriptive set theory, mathematical modelli analysis, high-performance computing, stochastics, econometrics, financial mathematics, ma artificial intelligence with applications in continuum thermodynamics / theory of partial equations. The candidate has to have PhD in the relevant area not longer than 5 years and he/she cann of the citizenship of the Czech Republic. Workplace: School of Mathematics, Faculty of Mathematics and Physics, Charles University, Prague Contact person: Pavla Kučerová E-mail: kucerova(zavinac)karlin.mff.cuni.cz [ MAIL "kucerova(zavinac)karlin.mff.cuni.cz"] Position available from: January 1, 2024 Deadline date: July 15, 2023 Applicants should submit required documents [ URL "https://cuni.cz/UKEN-178.html#10"] to: kucerova(zavinac)karlin.mff.cuni.cz [ MAIL "kucerova(zavinac)karlin.mff.cuni.cz"] (project and in a copy to ovzs(zavinac)dekanat.mff.cuni.cz [ MAIL "ovzs(zavinac)dekanat.mff.cuni.cz coordinator of the Junior Fund) _____________________________________________________________________________ |4| Title of the research project: CALL FOR JUNIOR (POSTDOC) POSITION IN THE AREA: NOBLE LIQUID CALORIMETER FOR FUTURE Post-doc position for two-year period from 1st January 2024 Applications are invited for a postdoc position at School of Mathematics, Faculty of Mathe Physics, Charles University in Prague, Czech Republic. The position is for two years start 1, 2024. Research Project Future Circular Collider (FCC) [1] is a proposal for the next collider at CERN area after is over. The first stage of the project is the electron-positron collider FCC-ee. The R&D the design of the detectors planned for the experiments at the FCC-ee have started recentl involved in the development of the high granular noble liquid calorimeter which is conside for the electromagnetic calorimeter. The noble liquid calorimeters have proved a very good performance in a number of experimen H1, NA48/62, ATLAS). The linearity and stability of the response, high resolution of energ very good position and timing resolution, particle identification capabilities and radiati are the main advantages of the concept. A new design with finely segmented straight read-o allows for high segmentation which is one of the key requirements for the future calorimet calorimeter proved very good performance in Monte Carlo simulations for FCC-hh [2]. The ca has been optimised for the experiments at the FCC-ee [3]. Along with the detailed simulati prototypes of read-out electrodes have been tested. Our group is involved in the studies o of the electrodes and the Monte Carlo simulations of the detector. The collection of the s digitisation is to be simulated and optimised. Moreover, the candidate is expected to cont software development, especially the implementation of the advanced reconstruction techniq learning, particle flow). This is crucial for improving the performance of the high granul We are looking for a candidate with experience in experimental particle physics, experienc and software development is an advantage. The candidate will join our group working on nob calorimetry for FCC. The work will include simulations of the signal digitisation needed f of the read-out chain and software development of the reconstruction algorithms in Key4HEP References: [1] FCC Collaboration (2019), Future Circular Collider Study Volumes I – III,  https://fcc [2] M. Aleksa et al (2019), Calorimeters for the FCC-hh, arXiv:1912.09962 [3] B. Francois (2022), Noble liquid calorimetry for a future FCC-ee experiment, https://d j.nima.2022.167035 [4] G. Ganis, C. Helsens, V. Völkl (2021), Key4hep, a framework for future HEP experiments and its use in FCC, http://dx.doi.org/10.48550/ARXIV.2111.09874 [ URL "http://dx.doi.org/1 ARXIV.2111.09874"] . Workplace: Department of Nuclear Physics and Nuclear Centrum, V Holešovičkách 747/2, 180 0 Contact person: Jana Faltová E-mail: jana.faltova(zavinac)mff.cuni.cz [ MAIL "jana.faltova(zavinac)mff.cuni.cz"] Position available from: January 1, 2024 Deadline date: July 15, 2023 Applicants should submit required documents [ URL "https://cuni.cz/UKEN-178.html#10"] to: jana.faltova(zavinac)mff.cuni.cz [ MAIL "jana.faltova(zavinac)mff.cuni.cz"] (project super copy to ovzs(zavinac)dekanat.mff.cuni.cz [ MAIL "ovzs(zavinac)dekanat.mff.cuni.cz"] (facul the Junior Fund) _____________________________________________________________________________ |5| Title of the research project: CALL FOR JUNIOR (POSTDOC) POSITION IN THE AREA OF FUNDAMENTAL QUESTIONS OF DISCRETE Post-doc position for two-year period from 1st January 2024             Applications are invited for a postdoc position at Department of Applied Mathematics, Char Prague, Czech Republic. Research Project The project is focused on selected fundamental questions of discrete and computational geo include questions around the Erdős-Szekeres Happy Ending theorem, on crossing numbers of g in Euclidean space, semialgebraic hypergraphs, and on Delauney graphs. The postdoc will wo consisting of senior and junior researchers and international postdocs, aiming at a crucia solution of fundamental problems in these areas. We are looking for a highly qualified and motivated researcher with a strong publication r journals and/or high-quality selective conference proceedings in the relevant area. The ge the team shall also be taken into account. Workplace: Department of Applied Mathematics   Contact person: Pavel Valtr E-mail:valtr(zavinac)kam.mff.cuni.cz [ MAIL "valtr(zavinac)kam.mff.cuni.cz"] Position available from: January 1, 2024 Deadline date: July 15, 2023 Applicants should submit required documents [ URL "https://cuni.cz/UKEN-178.html#10"] to: valtr(zavinac)kam.mff.cuni.cz [ MAIL "valtr(zavinac)kam.mff.cuni.cz"] (project supervisor) to ovzs(zavinac)dekanat.mff.cuni.cz [ MAIL "ovzs(zavinac)dekanat.mff.cuni.cz"] (faculty co Junior Fund) ****************************************************************************************** * Faculty of Science ****************************************************************************************** |1| Title of the research project: POPULATION AND STRUCTURAL GENOMICS OF CONVERGENT PLANT ADAPTATION We seek a highly motivated, independent early career researcher interested in joining a re within the context of a high-competitive Starting ERC and Junior Star projects with a poss for further independent early-career projects. The successful candidate will join the inte team of Ecological Genomics at Charles University in Prague, lead by Filip Kolář and will into a broad network of local and international collaborators. Evolution is driven by a combination of deterministic forces and stochasticity, whose rela however, remains a matter of debate. Knowing how predictable is evolution can provide insi predictive evolution of crops, pathogens or species under climate change. This project will address genomic basis and ecological consequences of convergent genome e natural environments. By leveraging fascinating natural diversity of European Brassicaceae repeatedly adapted to exceptionally strong selective pressure, toxic serpentine soils, the at uncovering general mechanisms determining which portion of the genome evolves in a pred The successful candidate will use long-read sequencing data of multiple plant species to a references and identify structural variation. By integrating these findings with available population-level genomic and transcriptomic data, they will identify convergent adaptive g and use comparative genomic approaches to infer the drivers of genomic convergence across project builds on our previous research in natural Arabidopsis populations (e.g. Konečná e Bohutínská et al. 2021) but will extend well beyond this system in order to discern genera the head-start with available data, the candidate is expected to be fully involved in the design and will lead the analytical part of the project. The candidate shall have (i) a keen interest in leading an independent research program wi collaborative research group, (ii) experience in handling large scale short- or long-read data, (iii) a strong background in structural, statistical, and/or population genomics and evolutionary biology, genetics, bioinformatics, or related fields. References Konečná V, Bray S, Vlček J, Bohutínská M, Požárová D, Roy Choudhury R, Bollmann-Giolai A, DE, Parisod C, Yant L, Kolář F(2021): Parallel adaptation in an autopolyploid is dominated recruitment of shared alleles. – Nature Communications. doi:10.1038/s41467-021-25256-5 Bohutínská M, Vlček J, Yair S, Laenen B, Konečná V, Fracassetti M, Slotte T, Kolář F (2021 basis of parallel adaptation varies with divergence in Arabidopsis and its relatives. – Pr National Academy of Sciences. doi:10.1073/pnas.2022713118. Salary: co-funding 1000 EUR/month is ensured Co-founding resources: Starting ERC project Double Adapt Department:Botany Supervisor: Filip Kolář E-mail: filip.kolar(zavinac)natur.cuni.cz [ MAIL "filip.kolar(zavinac)natur.cuni.cz"] Phone: +420 221 95 1638 Position available from: January 1, 2024 Deadline date for applications: July 25, 2023 Applicants must submit required documents [ URL "https://cuni.cz/UKEN-178.html#10"] to: filip.kolar(zavinac)natur.cuni.cz [ MAIL "filip.kolar(zavinac)natur.cuni.cz"] (project sup copy to pavla.pouskova(zavinac)natur.cuni.cz [ MAIL "pavla.pouskova(zavinac)natur.cuni.cz" Department) _____________________________________________________________________________ |2| Title of the research project: THERMO-HYDRO-MECHANICS OF LANDSLIDES UNDER CLIMATE CHANGE: FROM LOCAL PROCESSES TO The frequency and severity of landslides is changing worldwide because of climate change. complex phenomena, which involve hydro-mechanical processes in the ground in response to a interaction. These processes are influenced by temperature, and laboratory experiments ind main soil parameters (shear strength, compressibility, hydraulic conductivity) are sensiti variations (1–2 °C) in temperature. However, in temperate/warm climates (i.e., in non-free these thermal effects are not usually considered in slope stability models and, if they ar related to hydrological and biological processes and not to soil mechanical behaviours. Co role of climate change in temperate/warm climates may be underestimated. This could be esp for shallow (<10 m) landslides in clay soils – common in Europe (Czech Republic included) especially sensitive to thermodynamic disturbances. In this project, we will explore key aspects of temperature-dependent behaviours in soils modelling strategies accordingly, to take these behaviours into account. We will work at m through laboratory experiments under various thermal, hydraulic and mechanical conditions modelling at slope and regional scales via both physically-based and data-driven approache aim to propose a conceptual framework to evaluate whether observed (changes in) landslide explained according to temperature-dependent processes observed at small scale. More specifically, this fellowship is intended for a motivated postdoctoral candidate with in spatial and spatio-temporal modelling of landslides and a solid understanding of physic responsible for landslide triggering and propagation. The fellow will be responsible for c data-driven analyses (landslide susceptibility and hazard modelling) at the regional scale variety of methods rooted in geostatistics and machine learning. The analysis will focus o case studies in different climatic and lithological settings (e.g., in Central, Northern, Europe), with the goal of exploring the role of thermal forcing at different temporal scal term warming, seasonal oscillations, short-term heatwaves) on different types of landslide deep-seated, translational vs. rotational landslides, etc.) and learn how this combines wi changes in precipitation patterns and land use. Special attention will be paid to the inte explainability of the model results, the lack of which is a typical shortcoming in data-dr The fellow will explore novel AI-powered tools that are currently emerging, which aim at p explainability to patterns identified in a purely data-driven manner. At the same time, th collaborate with other team members within the project who will be carrying out physically at the slope and catchment scales for the same case studies as well as for virtual slope p work on understanding whether and why the observed/predicted patterns are or are not consi providing guidance on the upscalability/downscalability of landslide modelling approaches. Salary: co-founding 1000 EUR/month is ensured Co-founding resources: ERC CZ project THALIS – Thermally induced instability of slopes und (funds from MSMT, waiting for approval) Department: Institute of Hydrogeology, Engineering Geology and Applied Geophysics Supervisor: Gianvito Scaringi E-mail: gianvito.scaringi(zavinac)natur.cuni.cz [ MAIL "gianvito.scaringi(zavinac)natur.cu Phone: +420 777 546 432 Position available from: January 1, 2024 Deadline date for applications: July 25, 2023 Applicants must submit required documents [ URL "https://cuni.cz/UKEN-178.html#10"] to: gianvito.scaringi(zavinac)natur.cuni.cz [ MAIL "gianvito.scaringi(zavinac)natur.cuni.cz"] (project supervisor) and in a copy to pavla.pouskova(zavinac)natur.cuni.cz [ MAIL "pavla.pouskova(zavinac)natur.cuni.cz"] (International Department) _____________________________________________________________________________ |3| Title of the research project: SYNTHESIS OF NOVEL CYCLIC POLYCATIONS FOR ENHANCED GENE DELIVERY AND ANTIMICROBIAL The ever-increasing threats of antibiotic resistance and the expanding needs for improved techniques have urged researchers to explore new routes in polymer chemistry. This project and synthesize a series of novel cyclic polycations based on positively charged poly(2-oxa polyethylene imine [1,2]. It is hypothesized that these innovative polymers, characterized architectures and charge densities, can effectively perform in gene delivery applications roles, potentially surpassing their linear chain counterparts. Several synthetic strategies (such as cationic ring-opening polymerizations and subsequent polymerization modifications) will be utilized to yield cyclic polycations of different st and cycle sizes, ensuring high cyclization yields. The synthesis will be designed to produ of different charge densities and distributions, thereby allowing the study of structure-a relationships. Both physical and chemical characteristics of the synthesized cyclic polyme analyzed. Methods like nuclear magnetic resonance spectroscopy (NMR), size-exclusion chrom matrix-assisted laser desorption/ionization (MALDI) mass spectroscopy, and dynamic light s will be employed for the characterization. The solution properties of these polymers will their linear analogs to identify the benefits of cyclic architecture. Selected cyclic polycations will be assessed for their antimicrobial properties against an resistant bacteria (e.g., S. Aureus). The effectiveness of these new structures will be co the linear analogs, potentially illuminating new pathways in the fight against antibiotic Furthermore, the cyclic polycations will be utilized to form polyplexes with nucleic acids polyplexes will be studied for their potential in transfection, a key process in gene ther of these new cyclic polymers for gene delivery will be compared to linear counterparts to potential advantages. This comprehensive project holds significant potential to advance our understanding of cyc offering a unique perspective on their potential as effective antimicrobial agents and gen systems. Ultimately, our findings may provide new avenues for the development of advanced health sciences. References: [1] Zhou, Min, et al. Angew. Chem. Int. Ed. 59.16 (2020): 6412-6419. [2] Cortez, Mallory A., et al. J. Am. Chem. Soc. 137.20 (2015): 6541-6549. Salary: co-founding 1000 EUR/month is ensured Co-founding resources: Group of Polymer synthesis and Biomaterials, Department of Physical Macromolecular Chemistry Department: Department of Physical and Macromolecular Chemistry, faculty of Science Supervisor: Ondřej Sedláček, Ph.D. E-mail: sedlacek(zavinac)natur.cuni.cz [ MAIL "sedlacek(zavinac)natur.cuni.cz"] Phone: +420 221 951 311 Position available from: January 1, 2024 Deadline date for applications: July 25, 2023 Applicants must submit required documents [ URL "https://cuni.cz/UKEN-178.html#10"] to: sedlacek(zavinac)natur.cuni.cz [ MAIL "sedlacek(zavinac)natur.cuni.cz"] (project superviso copy to pavla.pouskova(zavinac)natur.cuni.cz [ MAIL "pavla.pouskova(zavinac)natur.cuni.cz" Department) _____________________________________________________________________________ |4| Title of the research project: STRUCTURE AND ONTOGENY OF CYTOSKELETAL APPARATUS IN FREE-LIVING FLAGELLATE PARATRIM Flagellar motility is widely distributed among eukaryotes. It is characteristic of many pr sperm cells of most plants and animals. Eukaryotic flagella are formed by basal bodies (ki which are cylindrical structures of nine microtubular triplets. Basal bodies (and the stru centrioles) are highly conserved and thought to function as templates for the microtubular the axoneme. The basal bodies are attached to a set of cytoskeletal elements which togethe basal bodies form the flagellar basal apparatus (mastigont). The basal body-associated str microtubular flagellar roots, fibers interconnecting basal bodies or connecting them with membrane or the cell nucleus, and fibers extending into the cytosol. At the end of the last century, excavate protists were recognized as a monophyletic group to similar morphological features. A typical excavate structure implies flagellate unicell with a feeding groove, a place on the surface of the cell that is used for food intake, su specific architecture of microtubular roots and associated fibers. Shortly after the defin group, hypotheses contradicting the monophyletic nature of these protists were proposed. T accumulation of data on the ultrastructure of the flagellate apparatus of different groups as well as confirmation in molecular phylogeny, we now assume that excavates represent a p group from which all other eukaryotes evolved. Given that excavates generally possess one elaborated mastigont and cytoskeletal apparati among eukaryotes, the interpretation of its elements represents the basis for understanding the evolutionary history of the last commo ancestor - LECA. In the proposed project, we will investigate the structure and ontogeny of mastigont in Paratrimastixpyriformis (Metamonada), the model organism in our laboratory. P.pyriformis i species characterized by a typical excavate morphology, i.e., suspension feeding groove an of which one is directed anteriorly (or antero-laterally), one posteriorly, and others lat posterior flagellum possesses two vanes with thickened vane margins. So far, no data are a cell division of species from this genus and the role of cytoskeletal elements in this pro the ultrastructure of P. pyriformis and its relatives has been investigated for the past f want to go a step further and investigate the details of the process of cell division and cytoskeleton. The aim of the project is to describe the process of cell division in Paratrimastix pyrifo emphasis on the flagellar apparatus roles of basal bodies and the inheritance of the cytos throughout the cycle. We will use antibodies staining alpha-tubulin to visualise microtubu house produce antibodies against striated fiber (SF)-assemblin which specifically stains r to the posterior basal body. Four types of microscopy will be applied: scanning electron m transmission electron microscopy, fluorescence microscopy and expansion microscopy. With s microscopy, the morphological aspect of cell division will be visualized, while transmissi microscopy will be used for visualization and ultrastructural analysis of basal bodies and microtubular elements in different phases of cell division. Special attention will be paid microscopy, a powerful super-resolution method that allows nanoscale imaging of specifical biological specimens using conventional microscopes. Salary: co-founding 1000 EUR/month is ensured Co-founding resources: GACR 23-07277S Department: Parasitology Supervisor: Vladimír Hampl E-mail: vlada(zavinac)natur.cuni.cz [ MAIL "vlada(zavinac)natur.cuni.cz"] Phone: +420325873952 Position available from: January 1, 2024 Deadline date for applications: July 27, 2023 Applicants must submit required documents [ URL "https://cuni.cz/UKEN-178.html#10"] to: Vladimír Hampl [ MAIL "vlada(zavinac)natur.cuni.cz"] (Project supervisor) and in a copy to pavla.pouskova(zavinac)natur.cuni.cz [ MAIL "pavla.pouskova(zavinac)natur.cuni.czz"] (Inte Department) _____________________________________________________________________________ |5| Title of the research project: MACHINE LEARNING FOR FLOOD AND DROUGHT MODELING UNDER CLIMATE CHANGE The changing patterns of extreme hydrological and meteorological phenomena, such as floods present significant challenges to both society and science. Accurately predicting and mode phenomena is crucial for effective disaster management, designing climate change adaptatio and sustainable water resources management. The coupled effects of climate change with con rapid landscape changes, such as forest disturbance, lead to increased uncertainty in hydr predictions. In this field, the role of Machine Learning (ML) and Artificial Intelligence as promising approaches enabling us to more reliably simulate dynamic natural systems unde boundary conditions, reducing uncertainties in predictions, and disentangling cross effect driving forces of hydrological change. The proposed research project aims to explore the potential and limitations of the use of Learning (ML) models coupled with data from automated hydrometeorological sensor networks. drought modeling will be done on different spatial and temporal scales, using the network catchments in montane catchments, from event-scale to long-term perspective. Simulations w hydrological extreme phenomena in mid-latitude montane basins, experiencing effects of cli forest disturbance, or land use change, being a sensible indicator of hydrological change. ML algorithms will be employed, such as SVM, ANN, CNN, LSTM, or DL. Data from the sensor n experimental catchments, comprising hydrological and meteorological monitoring at the high resolution, combined with long-term observations at complex basins and supporting spatial as a basis. We are seeking a highly motivated, independent, early-career researcher with a clear resea team spirit. The candidate should have a strong background in hydrology and/or geosciences hydrological modeling, hydroinformatics, and skills in machine learning and Python coding. candidate's independent research should be evidenced by relevant publications. This project will be carried out under the supervision and mentoring of prof. Jakub Langha candidate will be fully involved in the research activities of the Hydrology Research Grou hydro.natur.cuni.cz/ [ URL "http://hydro.natur.cuni.cz/"] ) at Faculty of Science, Charles It is expected that the candidate will be involved in the ongoing research projects focusi hydrological impacts of climate change on peat and snow hydrology, as well as in the broad activities, and will have the opportunity to collaborate with the partner team from the Un Zurich. We expect the candidate to publish results in high-quality hydrological journals s Hydrology, Hydrology and Earth System Sciences, or Water Research. Salary: co-founding 1000 EUR/month is ensured Co-founding resources: Department of Physical Geography and Geoecology Department: Department of Physical Geography and Geoecology Supervisor: prof. RNDr. Jakub Langhammer, Ph.D. E-mail: jakub.langhammer(zavinac)natur.cuni.cz [ MAIL "jakub.langhammer(zavinac)natur.cuni Phone: +420 - 739 488 268 Position available from: January 1, 2024 Deadline date for applications: July 21, 2023 Applicants must submit required documents [ URL "https://cuni.cz/UKEN-178.html#10"] to: jakub.langhammer(zavinac)natur.cuni.cz [ MAIL "jakub.langhammer(zavinac)natur.cuni.cz"] (project supervisor) and in a copy to pavla.pouskova(zavinac)natur.cuni.cz [ MAIL "pavla.pouskova(zavinac)natur.cuni.cz"] (International Department) _____________________________________________________________________________ |6| Title of the research project: COMPUTATIONAL MODELLING OF LASER PULSE INDUCED ULTRAFAST DYNAMICS IN SINGLE-ATOM PH Photocatalysis is an emerging technology with great potential for addressing energy shorta environmental pollution. Among the various types of photocatalysts, single-atom photocatal have demonstrated high effeciency and remarkable activity owing to their unique spatial se state, tunable coordination structure, and distinct local electronic properties. Gaining a understanding of the ultrafast catalytic processes induced by light is essential for the r design of photocatalysts, enabling enhanced photocatalytic performance and improved utiliz solar energy. In situ/operando characterization techniques, such as synchronous illuminati photoelectron spectroscopy (XPS), provide valuable insights into the dynamic changes in th geometry, and electronic structures of single atoms and their interactions with the cataly photocatalytic reactions. Additionally, these techniques offer crucial information for the highly efficient photocatalysts and the investigation of their underlying mechanisms. Despite the progress made through experimental studies, the interpretation of these phenom contentious. This is primarily attributed to the lack of ab initio understanding regarding of light-induced ultrafast excited carriers and structural changes occurring at the single photocatalysts. Bridging this gap between experimental observations and theoretical insigh to advance our understanding and enable the rational design of high performance SAPCs. On ab initio investigating light-driven ultrafast catalytic processes in photocalytic materia challenging due to the presence of phenomena such as ultrafast charge transfer, nonadiabat nuclei couplings, and the high computational cost. This project aims to investigate the laser pulse induced ultrafast electronic and structur of SAPCs based on nanomaterials (such as 2D materials, oxides, or zeolites) for applicatio splitting and CO2 reduction at the microscopic scale. The research will employ state-of-th time-dependent density functional theory (rt-TDDFT) and ab initio non-adiabatic molecular theory (surface hopping and Ehrenfest dynamics), to explore the ultrafast catalytic proces these SAPCs. Specifically, the project tasks will encompass: (i) Mechanism elucidation of photoexcited carrier separation and recombination at active s (ii) Investigation of vibrational model excitation and bond dynamics for adsorbed molecule H2O). (iii) Examination of the dynamic evolution of the valence state and coordination env the photocatalytic reaction process. (iv) Analysis of the solid-liquid interaction of nano active sites) under photoexcitation. (v) Study of the effects of defects and catalyst supp ultrafast catalytic processes. Publications of research group related to this topic: 1.J. He, S. Li, A. Bandyopadhyay, T. Frauenheim, Unravelling Photoinduced Interlayer Spin Dynamics in 2D Nonmagnetic-Ferromagnetic van der Waals Heterostructures, Nano Lett., 202 3237-3244. 2.J. He, S. Li, L. Zhou, T. Frauenheim, Ultrafast Light-Induced Ferromagnetic State in Tra Dichalcogenides Monolayers. J. Phys. Chem. Lett., 2022, 13, 2765-2771. 3.Z. Zhou, J. He, T. Frauenheim, O. V. Prezhdo, J. Wang, Control of Hot Carrier Cooling in Perovskites by Point Defects. J. Am. Chem. Soc., 2022, 144, 18126–18134. 4.S. Li, L. Zhou, T. Frauenheim, J. He, Light-Controlled Ultrafast Magnetic State Transiti Antiferromagnetic-ferromagnetic van der Waals Heterostructures. J. Phys. Chem. Lett., 20 6223-6229. 5.J. He, T. Frauenheim, Optically driven ultrafast magnetic order transitions in two-dimen ferrimagnetic MXenes. J. Phys. Chem. Lett., 2020, 11, 15, 6219–6226. Qualifications: A PhD degree in Computational Chemistry/Physics, Computational Materials Science or a rela is required, with experience in atomistic modelling of materials or first principles. Expe programming is highly desired. Salary: co-founding 1000 EUR/month is ensured Co-founding resources: Department of physical and macromolecular chemistry budget Department: Department of physical and macromolecular chemistry Supervisor: Junjie He, Ph.D. E-mail: junjie.he(zavinac)natur.cuni.cz [ MAIL "junjie.he(zavinac)natur.cuni.cz"] Position available from: January 1, 2024 Deadline date for applications: 27th July, 2023 Applicants must submit required documents [ URL "https://cuni.cz/UKEN-178.html#10"] to: junjie.he(zavinac)natur.cuni.cz [ MAIL "junjie.he(zavinac)natur.cuni.cz"] (project supervi copy to pavla.pouskova(zavinac)natur.cuni.cz [ MAIL "pavla.pouskova(zavinac)natur.cuni.cz" Department) _____________________________________________________________________________ |7| Title of the research project: ANTIFUNGAL PRODRUGS THAT EVADE DRUG RESISTANCE Invasive fungal infections are difficult to treat due to the increasing resistance of fung current treatment and the limited number of available antifungal drugs.1,2 In December 202 Organization (WHO) published the first list of priority fungal infections threatening publ Pathogenic fungi cause the most significant burden among susceptible individuals, e.g., im organ transplants, or cancer patients. Presence of fungal strains resistant to clinically represents the biggest challenge of current decade.               Fungal pathogens use several mechanisms leading to drug resistance ranging from drug efflu duplication or target site mutation.4,5 Moreover, resistant invasive mycoses can also deve resistance in response to the current treatment.6,7 Several species (e.g., Aspergillus) ha susceptibility to the currently used antifungal drugs resulting in pan-resistance. Prodrug antifungal drugs overrides toxicity of drugs and drug resistance of fungal pathogens by ci common biological barriers, and consequently saves time and money in developing new chemic Figure 1. a) Isavuconazole prodrug (Isavuconazolium sulfate, active drug isavuconazole is activation through plasma esterases). b) Permanent modification of Amphotericin B (AmB) le antifungals, secondarily lowering drug resistance. Aim of this proposal is the synthesis and development of non-targeted prodrugs of FDA-appr drugs to improve their pharmacokinetic properties, e.g., increasing solubility and lowerin design of prodrugs will be part of the research (here, we built on our previous experience of azole hybrids, prodrugs, and self-immolative linkers). The second part of the research the design and synthesis of targeted prodrugs that are recognized specifically by fungal p applicant should have good experience in both theoretical and practical organic chemistry. References: 1) M. Hoenigl, R. Sprute, M. Egger, A. Arastehfar, O. A. Cornely, R. Krause, C. Lass-Flörl Spec, G. R. Thompson, N. Wiederhold, J. D. Jenks, Drugs 2021, 81, 1703–1729. 2) W. Liu, L. Yuan, S. Wang, J. Med. Chem. 2020, 63, 12429–12459. 3) “WHO fungal priority pathogens list to guide research, development and public health ac found under https://www.who.int/publications/i/item/9789240060241. 4) T. Y. Hargrove, L. Friggeri, Z. Wawrzak, A. Qi, W. J. Hoekstra, R. J. Schotzinger, J. D Guengerich, G. I. Lepesheva, J. Biol. Chem.2017, 292, 6728–6743. 5) W. Chang, J. Liu, M. Zhang, H. Shi, S. Zheng, X. Jin, Y. Gao, S. Wang, A. Ji, H. Lou, N 91, 1–12. 6) L. W. Cheng, K. Land, Pharm. 2022, 15, 482. 7) M. A. Ghannoum, Y. Fu, A. S. Ibrahim, L. A. Mortara, M. C. Shafiq, J. E. Edwards, R. S. Antimicrob. Agents Chemother. 1995, 39, 2459–2465. 8) a) P. Šimon, M. Tichotová, M. G. Gallardo, E. Procházková, O. Baszczyňski,Chem. Eur. J. 12763–12775. b) E. Procházková, P. Šimon, M. Straka, J. Filo, M. Májek, M. Cigáň, O. Baszc Chem. Commun. 2021, 57, 211-214. c) O. Štěpánek, A. Čmoková, E. Procházková, V. Grobárová, Slapničková, A. Zíková, M. Kolařík, O. Baszczyňski, ChemMedChem 2022, e202200385. Workplace: Department of Organic Chemistry, Faculty of Science, Charles University Contact/supervisor: Ing. Ondřej Baszczyňski, Ph.D. Email: ondrej.baszczynski(zavinac)natur.cuni.cz [ MAIL "ondrej.baszczynski(zavinac)natur.c Position available from: January 1, 2024 (for 2 years) Deadline date for applications: 25th July, 2023 Applicants must submit required documents [ URL "https://cuni.cz/UKEN-178.html#10"] to: ondrej.baszczynski(zavinac)natur.cuni.cz [ MAIL "ondrej.baszczynski(zavinac)natur.cuni.cz" (project supervisor) and in a copy to pavla.pouskova(zavinac)natur.cuni.cz [ MAIL "pavla.pouskova(zavinac)natur.cuni.cz"] (International Department) _____________________________________________________________________________ |8| Title of the research project: EXPANDING OUR UNDERSTANDING ON THE MAJOR ASPECTS OF SEX CHROMOSOME EVOLUTION IN VER Recent genomic studies revealed a large variability of sex chromosomes in vertebrates, and the role of previously assumed general evolutionary drivers and other aspects of the sex c differentiation process. The long-term plan of the team is to expand our knowledge and cla of sexual antagonism, repetitive elements, chromosome rearrangements, gene dose regulatory function of sex determining loci in the differentiation rate of sex chromosomes, and to te and novel hypothesis in a comparative phylogenetic framework, examining vertebrate lineage independently co-opted the same genomic regions for the role of sex chromosome have solid working knowledge on bioinformatics with emphasis in genomics, tran analysis. Previous working experience with vertebrates or the evolution of sex but not mandatory. Salary: co-founding 1000 EUR/month is ensured Co-founding resources: GACR project 23-07347S Department: Dept. of Ecology, Faculty of Science, Charles University Supervisor: Michail Rovatsos E-mail: rovatsom(zavinac)natur.cuni.cz [ MAIL " rovatsom(zavinac)natur.cuni.cz Position available from: January 1, 2024 Deadline date for applications: 25th July, 2023 Applicants must submit required documents [ URL "https://cuni.cz/UKEN-178.html rovatsom(zavinac)natur.cuni.cz [ MAIL " rovatsom(zavinac)natur.cuni.cz"] (proj copy to pavla.pouskova(zavinac)natur.cuni.cz [ MAIL "pavla.pouskova(zavinac)na Department) ****************************************************************************** * Faculty of Law ****************************************************************************** |1| Title of the research project: LEGAL ASPECTS OF ARTIFICIAL INTELLIGENCE IN HEALTH CARE The introduction of artificial Intelligence to health care has a potential to whole field. The variety of AI tools usable in health care is almost endless, support systems to image interpretation in radiology to the use of embodied AI robotic surgery systems) to opening new horizons in telemedicine. At the same issues are similarly immense and complex. The use of AI in health care is like most pressing and discussed issues in law in the years to come, be it in the a protection, standard of care, patient’s autonomy of will and free informed con and criminal liability, or others. There will be a crucial need to analyse the propose options to address them. The post-doc researcher will narrow the scope to their interests and expertise. Workplace: Department of Medical Law, Faculty of Law, Charles University Contact/supervisor: doc. JUDr. Petr Šustek, Ph.D. E-mail: sustek(zavinac)prf.cuni.cz [ MAIL "sustek(zavinac)prf.cuni.cz "] Position available from: January 1, 2024 Deadline date for applications: July 17, 2023 Applicants must submit required documents [ URL "https://cuni.cz/UKEN-178.html sustek(zavinac)prf.cuni.cz [ MAIL "sustek(zavinac)prf.cuni.cz "] (project supe international(zavinac)prf.cuni.cz [ MAIL "international(zavinac)prf.cuni.cz"] _____________________________________________________________________________ |2| Title of the research project: SECURITY INCIDENT IN THE HEALTH CARE SECTOR The digitisation of health care industry in connection with the problematic ge today’s world emphasises the need to prepare for new security threats. Cyberse increasingly more important in the context of health care, protecting not only extensive financial loss and other resource reduction, but also lives and heal time, data protection in the broader sense brings about new and complex challe providers of health services, and other agents. Apart from these pressing issu the possibility of a physical attack on soft targets (especially patients and still all too real and requires effective and balanced response, which cannot outlined problems of cybersecurity and data protection as well as the protecti post-doc researcher will analyse these problems from the theoretical and/or pr choice. Workplace: Department of Medical Law, Faculty of Law, Charles University Contact/supervisor: doc. JUDr. Petr Šustek, Ph.D. for governance of one particular disruptive technology (for example hydrogen technologies etc.), or a cross-cutting topic, covering sev permitting scenarios, regulatory sandboxes etc.). The prospective p results of her/his research in journals, indexed in either WoS, or expected to present the outcomes of research at international confe precise publication strategy will be a clear benefit in the applica Workplace: Department of Administrative Law and Administrative Scie Contact/supervisor: Prof. JUDr. Jakub Handrlica, Ph.D., LL.M., DSc. "handrlic(zavinac)prf.cuni.cz"] Position available from: January 1, 2024 (for 24 months) Deadline date for applications: July 17, 2023 Applicants must submit required documents [ URL "https://cuni.cz/UK handrlic(zavinac)prf.cuni.cz [ MAIL "handrlic(zavinac)prf.cuni.cz"] international(zavinac)prf.cuni.cz [ MAIL "international(zavinac)prf ___________________________________________________________________ |4| Title of the research project: WATER LAW AND PROTECTION IN THE CZECH REPUBLIC AND ISRAEL ( EUROPEAN CONTEXT The research and the final monograph should be focused on the probl quantity as well as quality) in the valid legal regulations of Czec world leader in the water management and its legal regulation. The are general problems caused especially by the climate change. The m question of the good practice and its inspiration from the Czech Re mitigation as well as adaptation of the water management and treatm results may even be some drafts for the Czech and European legislat Workplace: Department of Environmental Law, Law Faculty of the Char University Contact/supervisor: Prof. JUDr. Milan Damohorský, DrSc., damohors(z "damohors(zavinac)prf.cuni.cz"] Position available from: January 1, 2024 Deadline date for applications: July 17, 2023 Applicants must submit required documents [ URL "https://cuni.cz/UK damohors(zavinac)prf.cuni.cz [ MAIL "damohors(zavinac)prf.cuni.cz"] international(zavinac)prf.cuni.cz [ MAIL "international(zavinac)prf ___________________________________________________________________ |5| Title of the research project: CONVENTION AND ITS APPLICATION AND ENFORCEMENT IN CZECHIA A The research and the final monograph should be focused on the probl water, land, nature and landscape in the valid legal regulations of Both countries are the member parties of the Carpathian Convention Protection and Sustainable Development of the Carpathians), adopted have the 20. anniversary) together with five other countries of the Serbia and Poland). Carpathian Convention is a good example of regi sustainable development and management of one of the largest Europe 190 000 km2). There are some troubles caused by climate change, bad forest manage the practice. The monograph should be concentrated on the question of the good pr Czech Republic (western part of Carpathians Mountains) and Ukraine Mountains) and vice versa in Europe. Both aspects – legal regulatio taken in account. The results may be even some drafts for Ukraine ( international law for its future legislation and decision making. Workplace: Department of Environmental Law, Law Faculty of the Char University Contact/supervisor: Prof. JUDr. Milan Damohorský, DrSc., damohors(z "damohors(zavinac)prf.cuni.cz"] Position available from: January 1, 2024 Deadline date for applications: July 17, 2023 Applicants must submit required documents [ URL "https://cuni.cz/UK damohors(zavinac)prf.cuni.cz [ MAIL "damohors(zavinac)prf.cuni.cz"] doc researcher would be to contribute to these discussi several of the institutions of transitional justice (to Workplace: Department of Public International Law, Facu Contact/supervisor: Prof. JUDr. PhDr. Veronika Bílková, "bilkova(zavinac)prf.cuni.cz"] Position available from: January 1, 2023 (for 24 months Deadline date for applications: July 17, 2023 Applicants must submit required documents [ URL "https: bilkova(zavinac)prf.cuni.cz [ MAIL "bilkova(zavinac)prf international(zavinac)prf.cuni.cz [ MAIL "international _______________________________________________________ |7| Title of the research project: CRISIS OF THE RULE OF LAW? For more than a decade now, we have witnessed a serious the world, including some of the EU members (especially only the insufficiency of the tools to counter the back various actors (States, international organizations suc lack of uniformity in the understanding of the rule of in the public and political space, less clear it is wha measured. The post-doc researcher will be expected to c the rule of law and its application with respect to the Workplace: Department of Public International Law, Facu Contact/supervisor: Prof. JUDr. PhDr. Veronika Bílková, "bilkova(zavinac)prf.cuni.cz"] Position available from: January 1, 2023 (for 24 months Deadline date for applications: July 17, 2023 Applicants must submit required documents [ URL "https: bilkova(zavinac)prf.cuni.cz [ MAIL "bilkova(zavinac)prf international(zavinac)prf.cuni.cz [ MAIL "international _______________________________________________________ |8| Title of the research project: TAX FAIRNESS AND BUDGETARY DETERMINATION OF SHAR The topic deals with tax justice and the budgetary dete the topic deals with both theoretical and practical asp be reflected in practically all Czech tax law, especial should focus on both horizontal and vertical tax justic preparation of an ideal model for the distribution of t The main emphasis will be on the issue of tax sovereign the model of fiscal federalism existing in the Czech Re extensively compared with foreign legal systems in orde Czech legal environment. Workplace: Department of Financial Law and Financial Sc Contact/supervisor: JUDr. Petr Kotáb, Ph.D., kotabp(zav kotabp(zavinac)prf.cuni.cz"] Position available from: January 1, 2023 (for 24 months Deadline date for applications: July 17, 2023 Applicants must submit required documents [ URL "https: kotabp(zavinac)prf.cuni.cz [ MAIL " kotabp(zavinac)prf. international(zavinac)prf.cuni.cz [ MAIL "international _______________________________________________________ |9| Title of the research project: THE INFLUENCE OF DIGITALISATION ON BUSINESS ENTR Commercial law, especially the regulation of business a massive wave of digitalization. A number of processes t paper to digital. An effort to eliminate the administrative burden, to st the transparency and credibility of business, the regis Deadline date for applications: July 17, 20 Applicants must submit required documents [ patek(zavinac)prf.cuni.cz [ MAIL "patek(zav international(zavinac)prf.cuni.cz [ MAIL "i ___________________________________________ |10| Title of the research project: IMPLEMENTING SPECIFIC CORPORATE GOVE REALLY MATTER IN CENTRALEUROPE? The rules of good corporate governance, esp to the perception of the doctrine, an integ Europe, especially in the post-socialist co is miles behind such developed capital mark main reasons why this is the case is the hi privatisation in Czechoslovakia, Poland or this reason, a number of changes that have law, particularly at the instigation of the embarrassments. The soft law rules and the number of specificities. On the other hand, stock companies across legal systems, apart basically identical elements (such as the a The aim of this joint research by a foreign is to analyse to what extent the rules tran best practices in post-socialist countries assess whether the historical experience an idiosyncratic approach. Workplace: Department of Business Law, Facu Contact/supervisor: doc. JUDr. Daniel Patěk "patek(zavinac)prf.cuni.cz"] Position available from: January 1, 2024 (f Deadline date for applications: July 17, 20 Applicants must submit required documents [ patek(zavinac)prf.cuni.cz [ MAIL "patek(zav international(zavinac)prf.cuni.cz [ MAIL "i ******************************************* * Faculty of Medicine in Pilsen ******************************************* |1| Title of the research project: MITOCHONDRIAL BIOGENESIS AND MTDNA Q Input premise There is mitochondrial inheritance down the mitochondria is crucial for the health of o renewal and autophagy, the activity of mito quality are still not understood. The proje treatment, advanced maternal age) on transg mitochondrial capacity will be assessed, an knowledge of the sensitivity of oocytes to medicine and assisted reproduction. Qualifications • Ph.D.(orequivalent)degreeinlife sciences, • Excellent English communication skills bo • Adequate publication activity • Skills with gamete isolation and manipula • Perfect communicationand ability to work Department: Biomedical Center Laboratory: Laboratory of Reproductive Medi _______________________________ |2| Title of the research proje INJECTABLE HYDROGELS FOR Input premise Bone tissue engineering, which dimensional porous scaffolds, r regenerate bone and cartilage t prepared scaffold, or by inject prefabricated scaffold with see inserted directly into the defe process. Injectable hydrogels i to absorb significant amount of biocompatibility. The specific it becomes a carrier for cells of natural and synthetic polyme engineering could make an impor in vivo conditions. When a comp tissues, is prepared, the insuf properties of injectable hydrog biocompatibility, cell binding, The research will be focused on testing. The main aim is to pre and biocompatibility. This inje differentiation of bone mesench on the expression of selected o regenerate bone and cartilage t Qualifications • Ph.D. (or equivalent) degree max. 5 years from graduation • Excellent English communicati • Working experience in a chemi biology • Reliability, responsibility, independently • Experience in writing scienti least 5 publications in journal • High motivation, ability to c • Analytical thinking, ability Department: Department of Medic Supervisor: Ing. Petra Chochola E-mail: petra.chocholata(zavina Phone: +420 377 593 286 Position available from: Januar Deadline date for applications: Applicants must submit required petra.chocholata(zavinac)lfp.cu and in a copy to Jitka.Skrabalo ******************************* * Faculty of Pharmacy in Hradec ******************************* |1| Title of the research proje INNOVATIVE APPLICATIONS The postdoc position is open fo separation methods. The applica · Ph.D. degree in a · Skills to work in · Strong background · Good written and · Knowledge of MS O · Experience with s · Knowledge of mass · Knowledge of desi · Ability to work i Supervisor: PharmDr orcid.org/0000-0002 [ URL "https://port Email: jac_p9aa(zav Phone: +420 495 067 Position available Deadline date for a Applicants must sub description of prio PharmDr. Pavel Jáč, the copy to faculty "nohejlk(zavinac)fa ___________________ |2| Title of the re COOPERATIVE Description: Chalcogen atoms can Precise considerati organocatalysts. Th combines electrophi laboratory.  Requirements for ap • completed doctora advantageous), • experience in the • active English sk • prerequisites for research), • flexibility, grea • good organization • ability to work b • high motivation a • strong willingnes Salary: Co-funding Supervisor: Dr. Mgr Email: hodikt(zavin Phone: +420 495 067 Workplace/Instituti of Pharmacy in Hrad Position available Deadline date for a Applicants must sub description of prio Dr. Mgr. Ing. Tomas the copy to faculty "nohejlk(zavinac)fa