Oncology












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            * Oncology
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            * Experimental oncology

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            covers mechanisms of regulations of basic cell biological programs connected with oncogene
            microenvironment, apoptosis, proliferation, differentiation, adhesion, migration, invasion

            mesenchymal transition, immunosurveilance).




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            * Oncohaematology
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            molecular regulatory mechanisms of blood cell differentiation and their pathologies. Basic

            translational research in the field. Namely childhood leukemias, morbus Hodgkin and haemat




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            * Solid tumors

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            namely neurooncology, oncogynaecology, oncourology, pancreatic and skin cancers. Individua
            radical surgical treatment, ultrasound implementation into the gynecological oncology, her

            and epigenetic alterations in prediction and early detection of cancer. Optimization of di
            and therapeutic processes, establishment of complex biobank. Studies of in vivo homing of 
            cells, tumor immunology, monitoring of the response to treatment in multiple myeloma, extr

            photopheresis. Characteristics of the mechanisms of the effectiveness of anticancer agents
            circulating cancer cells, advanced techniques of radiotherapy.






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            * Selected outputs
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            • MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia. V
              N, Burda P, Basova P, Kulvait V, Pospisil V, Savvulidi F, Kokavec J, Necas E, Berkova A,
              Karban J, Mraz M, Pospisilova S, Mayer J, Trneny M, Zavadil J, Stopka T. Blood, (2011)11

              IF: 9.898
            • Aggressive acute myeloid leukemia in PU.1/p53 double-mutant mice. Basova P, Pospisil V, 
              Burda P, Vargova K, Stanek L, Dluhosova M, Kuzmova E, Jonasova A, Steidl U, Laslo P, Sto

              (2014) 33(39):4735-45. IF: 8.56
            • Stary, J., M. Zimmermann, M. Campbell, L. Castillo, E. Dibar, S. Donska, A. Gonzalez, S.
              Janic, J. Jazbec, J. Konja, E. Kaiserova, J. Kowalczyk, G. Kovacs, C. K. Li, E. Magyaros

              Stark, Y. Jabali, J. Trka, O. Hrusak, H. Riehm, G. Masera and M. Schrappe. "Intensive Ch
              Childhood Acute Lymphoblastic Leukemia: Results of the Randomized Intercontinental Trial
              2002." J Clin Oncol 32, no. 3, (2014): 174-84. IF=19,96

            • Slamova, L., J. Starkova, E. Fronkova, M. Zaliova, L. Reznickova, F. W. van Delft, E. Vo
              Volejnikova, Z. Zemanova, K. Polgarova, G. Cario, M. Figueroa, T. Kalina, K. Fiser, J. P
              Bornhauser, M. Dworzak, J. Zuna, J. Trka, J. Stary, O. Hrusak and E. Mejstrikova. "Cd2-P

              Precursor Acute Lymphoblastic Leukemia with an Early Switch to the Monocytic Lineage." L
              3 (2014): 609-20. IF=9,379
            • Rob L, Škapa P, Robová H: Fertility- sparing surgery in patiens with cervical cancer. La

              (2011); 12, 192-200   (ISSN 1470-2045), IF=25.12
            • Šedo A., Mentlein, R.(Eds.): Glioma Cell Biology, Springer pp., 1-468, (2014)-ISBN 978-3