Neurosciences












            ******************************************************************************************

            * Neurosciences
            ******************************************************************************************
            Neurodegeneration is among the main priorities of European biomedical research due to a si

            increase in the incidence of neurodegenerative diseases linked to aging populations in dev
            Research teams of neurological and psychiatric clinics in collaboration with other CU inst
            involved in this research by studying the mechanism of neurodegeneration in Parkinson’s di

            extrapyramidal disorders, where the work focuses mainly on the genetic background, pathoph
            mechanisms and early biomarkers of neurodegeneration, including sleep and wakefulness diso
            The research of Alzheimer’s disease and other dementias includes longitudinal studies in t

            population focused on risk factors, biomarkers and the possibility of an intervention in e
            neurodegenerative diseases.

            Unknown mechanisms of activation of the memory trace and its propagation across chained ne
            also studied using neurophysiological methods. This makes it possible to understand the pa
            of memory disorders, in particular the development of Alzheimer’s disease studied in trans

            models. Neuroscience research teams of CU are also engaged in the study of diagnostic mark
            relationship between clinical, imaging, genetic and immunological parameters in multiple s
            other demyelinating and autoimmune diseases. Programmes focused on spasticity mechanisms a

            to influence them in multiple sclerosis and chronic spinal cord injury are also related to
            Genetic bases and mechanisms of development of impairment in congenital development disord
            particular focus on childhood seizure disorders are another important item. The research f

            neurobiological mechanisms and possibilities of their prevention in psychotic disorders, m
            and other neuropsychiatric disorders, including eating disorders. Last but not least, many
            neuropsychopharmacology of pain and drug addiction are in progress.






            ******************************************************************************************
            * Selected outputs

            ******************************************************************************************
            • Sieger T, Serranová T., Růžička F, Vostatek P, Wild J, Šťastná D, Bonnet C, Novák D, Růž
              D, Jech R. Distinct populations of neurons respond to emotional valence and arousal in t

              subthalamic nucleus. PNAS 2015; doi:10.1073/pnas.1410709112
            • Nytrova P, Potlukova E, Kemlink D, Woodhall M, Horakova D, Waters P, Havrdova E, Zivorov
              Trendelenburg M. Complement activation in patients with neuromyelitis optica. J Neuroimm

              15;274(1-2):185-91.
            • HÁJEK, T., CALKIN, C., BLAGDON, R., SLANEY, C., ALDA, M. Type 2 diabetes mellitus: a pot
              modifiable risk factor for neurochemical brain changes in bipolar disorders. Biological 

              2014, 77(3), 295-303. ISSN 0006-3223. DOI: 10.1016/j.biopsych.2013.11.007. IF 9.472
            • HORÁČEK, J., MIKOLÁŠ, P., TINTĚRA, J., NOVÁK, T., PÁLENÍČEK, T., BRUNOVSKÝ, M., HÖSCHL, 
              Sad mood induction has an opposite effect on amygdala response to emotional stimuli in e

              with bipolar disorder and healthy controls. Journal of Psychiatry & Neuroscience. 2014, 
              1180-4882. DOI: 10.1503/jpn.140044. IF 7.492