Metabolism












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            * Metabolism
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            Study of metabolic and endocrine diseases involves the genetic, biochemical, molecular, an

            mechanisms in their development which may be used both in animal models and in human medic
            errors of metabolism and their early diagnosis and treatment are one of the key pillars in
            research. The intensive study is concentrated on the early stages of obesity, nutrition di

            metabolism and diabetes as well as on the research of adipose tissue and on its regulatory
            development of widely occuring metabolic diseases supports the studies of the pathogenesis
            with orientation to the vessel wall impairment and the markers of these changes. The inter

            metabolic diseases involving the non-pharmacological (nutritional, regimen or surgical int
            pharmacological treatments are evaluated with the help of molecular biology and immunology

            of markers characterized the oxidative stress and subclinical inflammation. The discoverie
            as the effective sources for the prevention. The endocrine disorders involve the diagnoses
            of the inflammatory and tumor processes of all endocrine organs including the research of 

            effects and their influence on gravidity.





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            * Selected outputs
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            • Hodulova, M, Šedová, L, Křenová, D, Liška, F, Krupkova, M, Kazdova, L, Tremblay, J, Hame

              Šeda, O: Genomic Determinants of Triglyceride and Cholesterol Distribution into Lipoprot
              the Rat. PLOS ONE 9, 2014, Article Number: e109983
            • Stránecký V, Hoischen A, Hartmannová H, Zaki MS, Chaudhary A, Zudaire E, Nosková L, Bare

              Přistoupilová A, Hodaňová K, Sovová J, Hůlková H, Piherová L, Hehir-Kwa JY, de Silva D, 
              Farrag S, Zeman J, Martásek P, Baxová A, Afifi HH, St Croix B, Brunner HG, Temtamy S, Km
              in ANTXR1 cause GAPO syndrome. Am J Hun Genet 92, 2013, 792-799.

            • Škrha J jr, Kalousová M, Švarcová J, Muravská A, Kvasnička J, Landová L, Zima T, Škrha J
              of soluble RAGE and RAGE ligands HMGB1 and EN-RAGE to endothelial dysfunction in Type 1 
              diabetes mellitus. Exp Clin Endocrinol Diabetes 120, 2012, 277-281.

            • Rossmeislová L, Malisová L, Kračmerová J, Tencerová M, Kovácová Z, Koc M, Šiklová-Vítkov
              N, Langin D, Štich V: Weight loss improves the adipogenic capacity of human preadipocyte
              their secretory profile. Diabetes 62, 2013, 1990-1995.