Cardiovascular diseases












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            * Cardiovascular diseases
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            The research of cardiovascular diseases at the faculties of Charles University has a long 

            1930, Otto Klein from the Faculty of Medicine in Prague published his unique cardiac outpu
            results in 11 patients.  It was the world’s first diagnostic cardiac catheterisation in hu
            tradition continues today – the invasive cardiology area, including hemodynamic and therap

            interventions is still the most successful area of cardiovascular research at CU. The high
            of the European Society of Cardiology in 2014 – the Gold Medal was awarded to Petr Widimsk
            research results in the field of transcatheter treatment of myocardial infarction. Other a

            of cardiovascular diseases at all Five Faculties of Medicine of the CU include:
            treatment and imaging techniques in coronary heart disease, cardiomyopathy and myocarditis

            hypertension, peripheral vascular disease, heart failure, arterial hypertension, preventiv
            invasive diagnostics and therapy, physiology and pathophysiology of pulmonary circulation,
            syndromes and thrombosis, reperfusion therapy of acute strokes, new technologies in interv

            cardiology, surgical and interventional treatment of arrhythmias and new biological marker
            factors and pharmacological and non?pharmacological treatment.
            The research thus effectively covers the entire spectrum of cardiovascular diseases, and a

            of Medicine are involved, which cooperate on many projects (e.g. the internationally uniqu
            clinical trials “PRAGUE”).




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            * Selected outputs
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            • Widimsky P, Koznar B, Peisker T, Vasko P, Vavrova J, Stetkarova I. Direct catheter-based

              in acute ischaemic stroke performed collaboratively by cardiologists, neurologists and r
              single-centre pilot experience (PRAGUE-16 study). EuroIntervention. 2014 Nov;10(7):869-7
            • Rosa J, Widimský P, Toušek P, et al. Randomized comparison of renal denervation versus i

              pharmacotherapy including spironolactone in true-resistant hypertension: six-month resul
              prague-15 study. Hypertension. 2015 Feb;65(2):407-13
            • Kočka V, Malý M, Toušek P, Buděšínský T, Lisa L, Prodanov P, Jarkovský J, Widimský P.Bio

              vascular scaffolds in acute ST-segment elevation myocardial infarction: a prospective mu
              'Prague 19'. Eur Heart J. 2014 Mar;35(12):787-94
            • Budera P, Straka Z, Osmančík P, Vaněk T, Jelínek S, Hlavička J, Fojt R, Červinka P, Hulm

              Šmíd M, Malý M, Widimský P. Comparison of cardiac surgery with left atrial surgical abla
              cardiac surgery without atrial ablation in patients with coronary and/or valvular heart 
              atrial fibrillation: final results of the PRAGUE-12 randomized multicentre study. Eur He

              Nov;33(21):2644-52. (IF 10,478)
            • Veselka J, Krejčí J, Tomašov P, Zemánek D. Long-term survival after alcohol septal ablat
              for hypertrophic obstructive cardiomyopathy: a comparison with general population. Eur H

              2014;35:2040-5.
            • Stěrba M, Popelová O, Vávrová A, Jirkovský E, Kovaříková P, Geršl V, Simůnek T. Oxidativ
              signaling, and metal chelation in anthracycline cardiotoxicity and pharmacological cardi

              Antioxid Redox Signal. 2013 Mar 10;18(8):899-929. doi: 10.1089/ars.2012.4795. IF 7,667