Development of novel drugs against tuberculosis and its multidrug-resistant form












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            * Development of novel drugs against tuberculosis and its multidrug-resistant forms
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            The project deals with the development of novel antitubercular agents active against resis

            of Mycobacterium tuberculosis, dissemination of which is a serious global problem. The pro
            on the collaboration of the Faculty of Pharmacy of the Charles University in Prague, Centr
            Defence in Těchonín, and Faculty of Natural Sciences of the Comenius University in Bratisl

            Pharmacy deals with the design and synthesis of new molecules, evaluation of their toxicit
            antimycobacterial activity, Faculty of Natural Sciences in Bratislava deals with the deter
            their mechanism of action. The evaluation of in vivo antimycobacterial activity is perform

            Biological Defence in Těchonin, specialized institute fully equipped for handling with the
            infection agents.





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            * Selected outputs
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            • WO2016/091228 A1 (PCT/CZ2015/000126) Roh J., Němeček J., Hrabálek A., Klimesova V., Kara
              Pavek P., Sychra P. Substituted phenyltetrazole, its use and pharmaceutical preparation 
              same

            • G. Karabanovich, J. Zemanová, T. Smutný, R. Székely, M. Šarkan, I. Centárová, A. Vocat, 
              Čonka, J. Němeček, J. Stolaříková, M. Vejsová, K. Vávrová, V. Klimešová, A. Hrabálek, P.
              Cole, K. Mikušová, J. Roh.* Development of 3,5-Dinitrobenzylsulfanyl-1,3,4-Oxadiazoles a

              as Selective Antitubercular Agents Active Against Replicating and Nonreplicating Mycobac
              tuberculosis. J. Med. Chem. 2016, 59, 2362?2380.
            • Karabanovich G., Roh J., Smutný T., Němeček J., Vicherek P., Stolaříková J., Vejsová M.,

              Vávrová K., Pávek P., Klimešová V., Hrabálek A. 1-Substituted-5-[(3,5-dinitrobenzyl)sulf
              tetrazoles and their isosteric analogues: A new class of selective antitubercular agents
              drug-susceptible and multidrug-resistent mycobacteria. Eur. J. Med. Chem. 82, 2014, p. 3