Professor Škrha focuses mostly on the biochemistry and pathophysiology of diabetes and its complications. As the lead researcher, he has been in charge of 8 grant projects (IGA, GAČR, GAUK), one of which has won the Minister of Health Award. He leads a PRVOUK research project at the 1st Faculty of Medicine, Charles University. He is the author of five monographs, a number of chapters in monographs, and more than 300 professional articles in journals. Since 1990, he has been a member of the board of the Czech Diabetes Society and he is also the vice-chairman of the Czech Medical Association of J. E. Purkyně. He has been a member of the boards of foreign associations (European Association for the Study of Diabetes – EASD) and of the Federation of the Danube Symposia. He is the vice-president of the European Union of Medical Specialists based in Brussels.